Cell Biology Antibodies 7
Anti-ARF4 Antibody (CAB16759)
- SKU:
- CAB16759
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-ARF4 Antibody |
Antibody SKU: | CAB16759 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | IHC |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ARF4 (NP_001651.1). |
Application: | IHC |
Recommended Dilution: | IHC 1:50 - 1:200 |
Reactivity: | Human, Mouse |
Positive Samples: |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ARF4 (NP_001651.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MGLT ISSL FSRL FGKK QMRI LMVG LDAA GKTT ILYK LKLG EIVT TIPT IGFN VETV EYKN ICFT VWDV GGQD RIRP LWKH YFQN TQGL IFVV DSND RERI QEVA DELQ KMLL VDEL RDAV LLLF ANKQ DLPN AMAI SEMT DKLG LQSL RNRT WYVQ ATCA TQGT GLYE GLDW LSNE LSKR |
Gene ID: | 378 |
Uniprot: | P18085 |
Cellular Location: | Golgi apparatus, Lipid-anchor, Membrane |
Calculated MW: | 20kDa |
Observed MW: | Refer to figures |
Synonyms: | ARF4, ARF2 |
Background: | This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. |
UniProt Protein Function: | ARF4: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. |
UniProt Protein Details: | Protein type:G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, ARF; G protein Chromosomal Location of Human Ortholog: 3p14.3 Cellular Component: cytosol; dendritic spine; membrane Molecular Function:ARF guanyl-nucleotide exchange factor activity; epidermal growth factor receptor binding; GTP binding; GTPase activity; protein binding Biological Process: cell migration; ER to Golgi vesicle-mediated transport; negative regulation of apoptosis; phospholipase D activation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid ADP-ribosylation; retrograde vesicle-mediated transport, Golgi to ER |
NCBI Summary: | This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P18085 |
NCBI GenInfo Identifier: | 114123 |
NCBI Gene ID: | 378 |
NCBI Accession: | P18085.3 |
UniProt Secondary Accession: | P18085,P21371, B2R7J7, |
UniProt Related Accession: | P18085 |
Molecular Weight: | 20511 Da |
NCBI Full Name: | ADP-ribosylation factor 4 |
NCBI Synonym Full Names: | ADP ribosylation factor 4 |
NCBI Official Symbol: | ARF4 |
NCBI Official Synonym Symbols: | ARF2 |
NCBI Protein Information: | ADP-ribosylation factor 4 |
UniProt Protein Name: | ADP-ribosylation factor 4 |
Protein Family: | Auxin response factor |
UniProt Gene Name: | ARF4 |
UniProt Entry Name: | ARF4_HUMAN |
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