Signal Transduction Antibodies 3
Anti-Aquaporin-8 Antibody (CAB8539)
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- SKU:
- CAB8539
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-Aquaporin-8 Antibody |
| Antibody SKU: | CAB8539 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human AQP8 (NP_001160.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse heart, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human AQP8 (NP_001160.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FIGC LSVI ENGT DTGL LQPA LAHG LALG LVIA TLGN ISGG HFNP AVSL AAML IGGL NLVM LLPY WVSQ LLGG MLGA ALAK AVSP EERF WNAS GAAF VTVQ E |
| Gene ID: | 343 |
| Uniprot: | O94778 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 27kDa |
| Observed MW: | 30kDa |
| Synonyms: | AQP8, AQP-8 |
| Background: | Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. |
| UniProt Protein Function: | AQP8: Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea. Belongs to the MIP/aquaporin (TC 1.A.8) family. |
| UniProt Protein Details: | Protein type:Channel, misc.; Transporter, aquaporin family; Membrane protein, integral; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 16p12 Cellular Component: intracellular canaliculus; intracellular membrane-bound organelle; apical part of cell; integral to plasma membrane; plasma membrane Molecular Function:water channel activity; glycerol channel activity Biological Process: glycerol transport; response to reactive oxygen species; cellular water homeostasis; transport; canalicular bile acid transport; water transport; transmembrane transport |
| NCBI Summary: | Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O94778 |
| NCBI GenInfo Identifier: | 47117819 |
| NCBI Gene ID: | 343 |
| NCBI Accession: | O94778.2 |
| UniProt Related Accession: | O94778 |
| Molecular Weight: | |
| NCBI Full Name: | Aquaporin-8 |
| NCBI Synonym Full Names: | aquaporin 8 |
| NCBI Official Symbol: | AQP8 |
| NCBI Official Synonym Symbols: | AQP-8 |
| NCBI Protein Information: | aquaporin-8 |
| UniProt Protein Name: | Aquaporin-8 |
| Protein Family: | Aquaporin |
| UniProt Gene Name: | AQP8 |
| UniProt Entry Name: | AQP8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AQP8 antibody (CAB8539) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 90s. |
 | Immunofluorescence analysis of C6 cells using AQP8 Rabbit pAb (CAB8539) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH/3T3 cells using AQP8 Rabbit pAb (CAB8539) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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