Signal Transduction Antibodies 3
Anti-Aquaporin-5 Antibody (CAB9927)
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- SKU:
- CAB9927
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-Aquaporin-5 Antibody |
| Antibody SKU: | CAB9927 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human AQP5 (NP_001642.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung, Rat lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human AQP5 (NP_001642.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TDSR RTSP VGSP ALSI GLSV TLGH LVGI YFTG CSMN PARS FGPA VVMN RFSP AHWV FWVG PIVG AVLA AILY FYLL FPNS LSLS ERVA IIKG TYEP DEDW E |
| Gene ID: | 362 |
| Uniprot: | P55064 |
| Cellular Location: | Apical cell membrane, Multi-pass membrane protein |
| Calculated MW: | 28kDa |
| Observed MW: | 28KDa |
| Synonyms: | AQP5, AQP-5, PPKB |
| Background: | Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. |
| UniProt Protein Function: | AQP5: Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Belongs to the MIP/aquaporin (TC 1.A.8) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter; Transporter, aquaporin family; Channel, misc.; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q13 Cellular Component: microvillus; endoplasmic reticulum; integral to plasma membrane; apical plasma membrane; basal plasma membrane; plasma membrane Molecular Function:protein binding; water channel activity; glycerol channel activity Biological Process: odontogenesis; glycerol transport; camera-type eye morphogenesis; cellular water homeostasis; water transport; carbon dioxide transport; pancreatic juice secretion; excretion; transmembrane transport; saliva secretion |
| NCBI Summary: | Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55064 |
| NCBI GenInfo Identifier: | 1703358 |
| NCBI Gene ID: | 362 |
| NCBI Accession: | P55064.1 |
| UniProt Secondary Accession: | P55064,Q6FGW8, |
| UniProt Related Accession: | P55064 |
| Molecular Weight: | 28,292 Da |
| NCBI Full Name: | Aquaporin-5 |
| NCBI Synonym Full Names: | aquaporin 5 |
| NCBI Official Symbol: | AQP5 |
| NCBI Official Synonym Symbols: | PPKB; AQP-5 |
| NCBI Protein Information: | aquaporin-5 |
| UniProt Protein Name: | Aquaporin-5 |
| Protein Family: | Aquaporin |
| UniProt Gene Name: | AQP5 |
| UniProt Entry Name: | AQP5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AQP5 antibody (CAB9927) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using AQP5 antibody (CAB9927) (40x lens). |
 | Immunofluorescence analysis of NIH/3T3 cells using AQP5 antibody (CAB9927) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U2OS cells using AQP5 antibody (CAB9927) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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