Cell Biology Antibodies 4
Anti-APOL3 Antibody (CAB13840)
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- SKU:
- CAB13840
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-APOL3 Antibody |
| Antibody SKU: | CAB13840 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human APOL3 (NP_663614.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | DU145, A-549, BxPC-3, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human APOL3 (NP_663614.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDSE KKRF TEEA TKYF RERV SPVH LQIL LTNN EAWK RFVT AAEL PRDE ADAL YEAL KKLR TYAA IEDE YVQQ KDEQ FREW FLKE FPQV KRKI QESI EKLR ALAN GIEE VHRG CTIS NVVS SSTG AASG IMSL AGLV LAPF TAGT SLAL TAAG VGLG AASA VTGI TTSI VEHS YTSS AEAE ASRL TATS IDRL KVFK EVMR DITP NLLS LLNN YYEA TQTI GSEI RAIR QARA RARL PVTT WRIS AGSG GQAE RTIA GTTR AVSR GARI LSAT TSGI FLAL DVVN LVYE SKHL HEGA KSAS AEEL RRQA QELE ENLM ELTQ IYQR LNPC HTH |
| Gene ID: | 80833 |
| Uniprot: | O95236 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 21kDa/36kDa/44kDa |
| Observed MW: | 38kDa |
| Synonyms: | APOL3, APOLIII, CG121, CG12_1, apoL-III |
| Background: | This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | APOL3: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. Belongs to the apolipoprotein L family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: membrane Molecular Function:lipid transporter activity; signal transducer activity Biological Process: inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade |
| NCBI Summary: | This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015] |
| UniProt Code: | O95236 |
| NCBI GenInfo Identifier: | 215274188 |
| NCBI Gene ID: | 80833 |
| NCBI Accession: | O95236.3 |
| UniProt Secondary Accession: | O95236,Q5U5N4, Q9BQ82, Q9BQA3, B1AHI4, B1AHI5, |
| UniProt Related Accession: | O95236 |
| Molecular Weight: | 44278 Da |
| NCBI Full Name: | Apolipoprotein L3 |
| NCBI Synonym Full Names: | apolipoprotein L3 |
| NCBI Official Symbol: | APOL3 |
| NCBI Official Synonym Symbols: | CG121; CG12_1; APOLIII; apoL-III |
| NCBI Protein Information: | apolipoprotein L3 |
| UniProt Protein Name: | Apolipoprotein L3 |
| UniProt Synonym Protein Names: | Apolipoprotein L-III; ApoL-III; TNF-inducible protein CG12-1; CG12_1 |
| Protein Family: | Apolipoprotein |
| UniProt Gene Name: | APOL3 |
| UniProt Entry Name: | APOL3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using APOL3 antibody (CAB13840) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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