Metabolism Antibodies 1

Anti-APOL1 Antibody (CAB13376)

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SKU:
CAB13376
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-APOL1 Antibody
Antibody SKU:CAB13376
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human APOL1 (NP_003652.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human APOL1 (NP_003652.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEGA ALLR VSVL CIWM SALF LGVG VRAE EAGA RVQQ NVPS GTDT GDPQ SKPL GDWA AGTM DPES SIFI EDAI KYFK EKVS TQNL LLLL TDNE AWNG FVAA AELP RNEA DELR KALD NLAR QMIM KDKN WHDK GQQY RNWF LKEF PRLK SELE DNIR RLRA LADG VQKV HKGT TIAN VVSG SLSI SSGI LTLV GMGL APFT EGGS LVLL EPGM ELGI TAAL TGIT SSTM DYGK KWWT QA
Gene ID:8542
Uniprot:O14791
Cellular Location:Secreted
Calculated MW:42kDa/43kDa/45kDa
Observed MW:44kDa
Synonyms:APOL1, APO-L, APOL, APOL-I, FSGS4
Background:This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:APOL1: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomerulosclerosis type 4 (FSGS4). It is a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Belongs to the apolipoprotein L family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Channel, chloride; Secreted; Secreted, signal peptide; Lipid-binding

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: extracellular region; extracellular space; intrinsic to membrane

Molecular Function:chloride channel activity; lipid binding; protein binding

Biological Process: cytolysis; innate immune response; killing of cells of another organism; receptor-mediated endocytosis

Disease: Focal Segmental Glomerulosclerosis 4, Susceptibility To

NCBI Summary:This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
UniProt Code:O14791
NCBI GenInfo Identifier:206729940
NCBI Gene ID:8542
NCBI Accession:O14791.5
UniProt Secondary Accession:O14791,O60804, Q5R3P7, Q5R3P8, Q96AB8, Q96PM4, Q9BQ03 A5PLQ4, B4DU12, E9PF24,
UniProt Related Accession:O14791
Molecular Weight:42,158 Da
NCBI Full Name:Apolipoprotein L1
NCBI Synonym Full Names:apolipoprotein L1
NCBI Official Symbol:APOL1  
NCBI Official Synonym Symbols:APOL; APO-L; FSGS4; APOL-I  
NCBI Protein Information:apolipoprotein L1
UniProt Protein Name:Apolipoprotein L1
UniProt Synonym Protein Names:Apolipoprotein L; Apo-L; ApoL; Apolipoprotein L-I; ApoL-I
Protein Family:Apolipoprotein
UniProt Gene Name:APOL1  
UniProt Entry Name:APOL1_HUMAN
Anti-APOL1 Antibody (CAB13376)Western blot analysis of extracts of mouse liver, using APOL1 antibody (CAB13376) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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