| UniProt Protein Function: | Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. |
| NCBI Summary: | This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011] |
| UniProt Code: | Q14114 |
| NCBI GenInfo Identifier: | 259016389 |
| NCBI Gene ID: | 7804 |
| NCBI Accession: | Q14114.4 |
| UniProt Secondary Accession: | Q14114,O14968, Q86V27, Q99876, Q9BR78, B1AMT6, B1AMT7 B1AMT8, |
| UniProt Related Accession: | Q14114 |
| Molecular Weight: | 106kDa |
| NCBI Full Name: | Low-density lipoprotein receptor-related protein 8 |
| NCBI Synonym Full Names: | LDL receptor related protein 8 |
| NCBI Official Symbol: | LRP8 |
| NCBI Official Synonym Symbols: | MCI1; LRP-8; APOER2; HSZ75190 |
| NCBI Protein Information: | low-density lipoprotein receptor-related protein 8 |
| UniProt Protein Name: | Low-density lipoprotein receptor-related protein 8 |
| UniProt Synonym Protein Names: | Apolipoprotein E receptor 2 |
| Protein Family: | Low-density lipoprotein receptor-related protein |
| UniProt Gene Name: | LRP8 |
