Name: Anti-APOC1 Antibody (CAB5629)
Brand: Cell Biology Antibodies 9
SKU: CAB5629
Availability: OutOfStock

Antibody Name:	Anti-APOC1 Antibody
Antibody SKU:	CAB5629
Antibody Size:	20uL, 50uL, 100uL
Application:	IHC
Reactivity:	Human, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-83 of human APOC1 (NP_001636.1).

Application:	IHC
Recommended Dilution:	IHC 1:50 - 1:100
Reactivity:	Human, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-83 of human APOC1 (NP_001636.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MRLF LSLP VLVV VLSI VLEG PAPA QGTP DVSS ALDK LKEF GNTL EDKA RELI SRIK QSEL SAKM REWF SETF QKVK EKLK IDS
Gene ID:	341
Uniprot:	P02654
Cellular Location:	Secreted
Calculated MW:	9kDa
Observed MW:

Synonyms:

APOC1, Apo-CI, ApoC-I, apo-CIB, apoC-IB

Background:

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

UniProt Protein Function:	APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family.
UniProt Protein Details:	Protein type:Secreted, signal peptide; Lipid-binding; Secreted; Inhibitor; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: chylomicron; endoplasmic reticulum Molecular Function:phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding Biological Process: positive regulation of catalytic activity; cholesterol metabolic process; triacylglycerol metabolic process; phospholipid efflux; negative regulation of lipid catabolic process; negative regulation of cholesterol transport; negative regulation of lipoprotein lipase activity; cholesterol efflux; lipoprotein metabolic process; negative regulation of receptor-mediated endocytosis; lipid metabolic process; negative regulation of lipid metabolic process; regulation of cholesterol transport; negative regulation of fatty acid biosynthetic process
NCBI Summary:	The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:	P02654
NCBI GenInfo Identifier:	114016
NCBI Gene ID:	341
NCBI Accession:	P02654.1
UniProt Secondary Accession:	P02654,Q6IB97, B2R526,
UniProt Related Accession:	P02654
Molecular Weight:	83
NCBI Full Name:	Apolipoprotein C-I
NCBI Synonym Full Names:	apolipoprotein C-I
NCBI Official Symbol:	APOC1
NCBI Official Synonym Symbols:	Apo-CI; ApoC-I
NCBI Protein Information:	apolipoprotein C-I; apo-CIB; apoC-IB; apolipoprotein C1; apolipoprotein C-I variant I
UniProt Protein Name:	Apolipoprotein C-I
UniProt Synonym Protein Names:	Apolipoprotein C1Truncated apolipoprotein C-I
Protein Family:	Apolipoprotein
UniProt Gene Name:	APOC1
UniProt Entry Name:	APOC1_HUMAN