Immunology Antibodies 1

Anti-APOBEC3D Antibody (CAB11648)

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SKU:
CAB11648
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-APOBEC3D Antibody
Antibody SKU:CAB11648
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 207-386 of human APOBEC3D (NP_689639.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, HepG2, 293T, Mouse spleen, Mouse liver, Mouse kidney, Rat liver, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 207-386 of human APOBEC3D (NP_689639.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AMYP HIFY FHFK NLLK ACGR NESW LCFT MEVT KHHS AVFR KRGV FRNQ VDPE THCH AERC FLSW FCDD ILSP NTNY EVTW YTSW SPCP ECAG EVAE FLAR HSNV NLTI FTAR LCYF WDTD YQEG LCSL SQEG ASVK IMGY KDFV SCWK NFVY SDDE PFKP WKGL QTNF RLLK RRLR EILQ
Gene ID:140564
Uniprot:Q96AK3
Cellular Location:Cytoplasm, P-body
Calculated MW:46kDa
Observed MW:43kDa
Synonyms:APOBEC3D, A3D, APOBEC3DE, APOBEC3E, ARP6
Background:This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.
UniProt Protein Function:APOBEC3D: Probable DNA cytidine deaminase involved in foreign DNA clearance. May provide cellular innate resistance to a specific panel of genetic invaders including endogenous retroelements and a subset of viruses. Belongs to the cytidine and deoxycytidylate deaminase family.
UniProt Protein Details:

Protein type:Hydrolase; EC 3.5.4.-

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cytoplasm

Molecular Function:zinc ion binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Biological Process: negative regulation of retroviral genome replication; innate immune response; defense response to virus

UniProt Code:Q96AK3
NCBI GenInfo Identifier:48474596
NCBI Gene ID:
NCBI Accession:Q96AK3.1
UniProt Secondary Accession:Q96AK3,Q5JZ91, Q7Z2N2, Q7Z2N5, Q7Z2N6,
Molecular Weight:46598
NCBI Full Name:DNA dC->
UniProt Protein Name:DNA dC->dU-editing enzyme APOBEC-3D
Protein Family:DNA dC->dU-editing enzyme
UniProt Gene Name:APOBEC3D  
UniProt Entry Name:ABC3D_HUMAN
Anti-APOBEC3D Antibody (CAB11648)Western blot analysis of extracts of various cell lines, using APOBEC3D antibody (CAB11648) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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