Immunology Antibodies 1

Anti-APOBEC3C Antibody (CAB14510)

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SKU:
CAB14510
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-APOBEC3C Antibody
Antibody SKU:CAB14510
Antibody Size:20uL, 50uL, 100uL
Application:WB IP
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human APOBEC3C (NP_055323.2).
Application:WB IP
Recommended Dilution:WB 1:500 - 1:2000 IP 1:50 - 1:100
Reactivity:Human
Positive Samples:K-562
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human APOBEC3C (NP_055323.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNPQ IRNP MKAM YPGT FYFQ FKNL WEAN DRNE TWLC FTVE GIKR RSVV SWKT GVFR NQVD SETH CHAE RCFL SWFC DDIL SPNT KYQV TWYT SWSP CPDC AGEV AEFL ARHS NVNL TIFT ARLY YFQY PCYQ EGLR SLSQ EGVA VEIM DYED FKYC WENF VYND NEPF KPWK GLKT NFRL LKRR LRES LQ
Gene ID:27350
Uniprot:Q9NRW3
Cellular Location:Cytoplasm, Nucleus
Calculated MW:22kDa
Observed MW:22kDa
Synonyms:APOBEC3C, A3C, APOBEC1L, ARDC2, ARDC4, ARP5, PBI, bK150C2.3
Background:This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.
UniProt Protein Function:APOBEC3C: Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family.
UniProt Protein Details:

Protein type:Hydrolase; EC 3.5.4.-; RNA-binding

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cytoplasm; nucleus

Molecular Function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; protein binding; zinc ion binding

Biological Process: cytidine deamination; defense response to virus; innate immune response; negative regulation of viral genome replication; viral reproduction

NCBI Summary:This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NRW3
NCBI GenInfo Identifier:48474983
NCBI Gene ID:27350
NCBI Accession:Q9NRW3.2
UniProt Secondary Accession:Q9NRW3,Q5JZ92, Q7Z2N7, Q96F12, B2R884,
UniProt Related Accession:Q9NRW3
Molecular Weight:22,826 Da
NCBI Full Name:DNA dC->
NCBI Synonym Full Names:apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C
NCBI Official Symbol:APOBEC3C  
NCBI Official Synonym Symbols:A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3  
NCBI Protein Information:DNA dC->dU-editing enzyme APOBEC-3C
UniProt Protein Name:DNA dC->dU-editing enzyme APOBEC-3C
UniProt Synonym Protein Names:APOBEC1-like; Phorbolin I
Protein Family:DNA dC->dU-editing enzyme
UniProt Gene Name:APOBEC3C  
UniProt Entry Name:ABC3C_HUMAN
Anti-APOBEC3C Antibody (CAB14510)Western blot analysis of extracts of K-562 cells, using APOBEC3C antibody (CAB14510) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-APOBEC3C Antibody (CAB14510)Immunoprecipitation analysis of 200ug extracts of K-562 cells, using 3 ug APOBEC3C antibody (CAB14510). Western blot was performed from the immunoprecipitate using APOBEC3C antibody (CAB14510) at a dilition of 1:1000.
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