Cell Biology Antibodies 7

Anti-APLP2 Antibody (CAB16755)

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SKU:
CAB16755
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-APLP2 Antibody
Antibody SKU:CAB16755
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 340-450 of human APLP2 (NP_001135750.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 340-450 of human APLP2 (NP_001135750.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RADM DQFT ASIS ETPV DVRV SSEE SEEI PPFH PFHP FPAL PENE GSGV GEQD GGLI GAEE KVIN SKNK VDEN MVID ETLD VKEM IFNA ERVG GLEE ERES VGPL REDF SLS
Gene ID:334
Uniprot:Q06481
Cellular Location:Cell membrane, Nucleus, Single-pass type I membrane protein
Calculated MW:59kDa/79kDa/80kDa/85kDa/86kDa/87kDa
Observed MW:Refer to figures
Synonyms:APLP2, APLP-2, APPH, APPL2, CDEBP
Background:This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
UniProt Protein Function:APLP2: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts. Belongs to the APP family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.; Cell surface; DNA-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: membrane; nucleus; plasma membrane; platelet alpha granule membrane

Molecular Function:identical protein binding; protein binding

Biological Process: platelet degranulation

NCBI Summary:This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
UniProt Code:Q06481
NCBI GenInfo Identifier:1703344
NCBI Gene ID:334
NCBI Accession:Q06481.2
UniProt Secondary Accession:Q06481,Q13861, Q14594, Q14662, Q71U10, Q7M4L3, Q9BT36 B3KXX9, H7BXI4,
UniProt Related Accession:Q06481
Molecular Weight:87,215 Da
NCBI Full Name:Amyloid-like protein 2
NCBI Synonym Full Names:amyloid beta precursor like protein 2
NCBI Official Symbol:APLP2  
NCBI Official Synonym Symbols:APPH; APPL2; CDEBP; APLP-2  
NCBI Protein Information:amyloid-like protein 2
UniProt Protein Name:Amyloid-like protein 2
UniProt Synonym Protein Names:APPH; Amyloid protein homolog; CDEI box-binding protein; CDEBP
Protein Family:Amyloid-like protein
UniProt Gene Name:APLP2  
UniProt Entry Name:APLP2_HUMAN
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