Cell Death Antibodies 2

Anti-APLP1 Antibody (CAB6870)

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SKU:
CAB6870
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-APLP1 Antibody
Antibody SKU:CAB6870
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 39-300 of human APLP1 (NP_005157.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 39-300 of human APLP1 (NP_005157.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SLAG GSPG AAEA PGSA QVAG LCGR LTLH RDLR TGRW EPDP QRSR RCLR DPQR VLEY CRQM YPEL QIAR VEQA TQAI PMER WCGG SRSG SCAH PHHQ VVPF RCLP GEFV SEAL LVPE GCRF LHQE RMDQ CESS TRRH QEAQ EACS SQGL ILHG SGML LPCG SDRF RGVE YVCC PPPG TPDP SGTA VGDP STRS WPPG SRVE GAED EEEE ESFP QPVD DYFV EPPQ AEEE EETV PPPS SHTL AVVG KVTP TPRP TDGV DIYF GM
Gene ID:333
Uniprot:P51693
Cellular Location:Cell membrane, Cytoplasm, Single-pass type I membrane protein
Calculated MW:72kDa
Observed MW:72KDa
Synonyms:APLP1, APLP
Background:This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:APLP1: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. Belongs to the APP family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; integral to membrane; plasma membrane; basement membrane

Molecular Function:heparin binding; identical protein binding; protein binding; alpha-2C adrenergic receptor binding; transition metal ion binding; alpha-2B adrenergic receptor binding; alpha-2A adrenergic receptor binding

Biological Process: regulation of translation; nervous system development; negative regulation of cAMP biosynthetic process; organ morphogenesis; extracellular matrix organization and biogenesis; apoptosis; forebrain development; mRNA polyadenylation; endocytosis; G-protein signaling, adenylate cyclase inhibiting pathway; cell adhesion

NCBI Summary:This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:P51693
NCBI GenInfo Identifier:28558769
NCBI Gene ID:333
NCBI Accession:P51693.3
UniProt Related Accession:P51693
Molecular Weight:70kDa
NCBI Full Name:Amyloid-like protein 1
NCBI Synonym Full Names:amyloid beta precursor like protein 1
NCBI Official Symbol:APLP1  
NCBI Official Synonym Symbols:APLP  
NCBI Protein Information:amyloid-like protein 1
UniProt Protein Name:Amyloid-like protein 1
Protein Family:Amyloid-like protein
UniProt Gene Name:APLP1  
UniProt Entry Name:APLP1_HUMAN
Anti-APLP1 Antibody (CAB6870)Western blot analysis of extracts of various cell lines, using APLP1 Rabbit pAb (CAB6870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-APLP1 Antibody (CAB6870)Immunohistochemistry of paraffin-embedded rat brain using APLP1 Rabbit pAb (CAB6870) at dilution of 1:100 (40x lens).
Anti-APLP1 Antibody (CAB6870)Immunofluorescence analysis of L929 cells using APLP1 antibody (CAB6870) at dilution of 1:100. Blue: DAPI for nuclear staining.
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