Cardiovascular Antibodies

Anti-APLNR Antibody (CAB14176)

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SKU:
CAB14176
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular

Description

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Antibody Name:Anti-APLNR Antibody
Antibody SKU:CAB14176
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 301-380 of human APLNR (NP_005152.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 301-380 of human APLNR (NP_005152.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NSCL NPFL YAFF DPRF RQAC TSML CCGQ SRCA GTSH SSSG EKSA SYSS GHSQ GPGP NMGK GGEQ MHEK SIPY SQET LVVD
Gene ID:187
Uniprot:P35414
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:42kDa
Observed MW:Refer to figures
Synonyms:APLNR, AGTRL1, APJ, APJR, HG11
Background:This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
UniProt Protein Function:AGTRL1: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:G-protein coupled receptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; regulation of body fluid levels; heart development; gastrulation

NCBI Summary:This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
UniProt Code:P35414
NCBI GenInfo Identifier:543823
NCBI Gene ID:187
NCBI Accession:P35414.1
UniProt Related Accession:P35414
Molecular Weight:380
NCBI Full Name:Apelin receptor
NCBI Synonym Full Names:apelin receptor
NCBI Official Symbol:APLNR  
NCBI Official Synonym Symbols:APJ; APJR; HG11; AGTRL1  
NCBI Protein Information:apelin receptor; APJ receptor; HG11 orphan receptor; APJ (apelin) receptor; angiotensin receptor-like 1; G protein-coupled receptor APJ; G-protein coupled receptor APJ; angiotensin II receptor-like 1; G-protein coupled receptor HG11
UniProt Protein Name:Apelin receptor
UniProt Synonym Protein Names:Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11
Protein Family:Apelin receptor
UniProt Gene Name:APLNR  
UniProt Entry Name:APJ_HUMAN
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