Cell Biology Antibodies 15
Anti-APLF Antibody (CAB17842)
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- SKU:
- CAB17842
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-APLF Antibody |
| Antibody SKU: | CAB17842 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-380 of human APLF (NP_775816.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-380 of human APLF (NP_775816.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LSVP AISG GNVI QGSG KEEI CKDK SQLN TTQQ GRRQ LISS GSSE NTSA EQDT GEEC KNTD QEES TISS KEMP QSFS AITL SNTE MNNI KTNA QRNK LPIE ELGK VSKH KIAT KRTP HKED EAMS CSEN CSSA QGDS LQDE SQGS HSES SSNP SNPE TLHA KATD SVLQ GSEG NKVK RTSC M |
| Gene ID: | 200558 |
| Uniprot: | Q8IW19 |
| Cellular Location: | |
| Calculated MW: | 56kDa |
| Observed MW: | 57kDa |
 | Western blot - APLF Rabbit pAb (CAB17842) |
| Synonyms: | APFL, C2orf13, PALF, Xip1, ZCCHH1, APLF |
| Background: | C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008] |
| UniProt Protein Function: | Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. |
| NCBI Summary: | C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8IW19 |
| NCBI GenInfo Identifier: | 27734905 |
| NCBI Gene ID: | 200558 |
| NCBI Accession: | NP_775816.1 |
| UniProt Secondary Accession: | Q8IW19,Q53P47, Q53PB9, Q53QU0, A8K476, |
| UniProt Related Accession: | Q8IW19 |
| Molecular Weight: | |
| NCBI Full Name: | aprataxin and PNK-like factor |
| NCBI Synonym Full Names: | aprataxin and PNKP like factor |
| NCBI Official Symbol: | APLF |
| NCBI Official Synonym Symbols: | APFL; PALF; Xip1; ZCCHH1; C2orf13 |
| NCBI Protein Information: | aprataxin and PNK-like factor |
| UniProt Protein Name: | Aprataxin and PNK-like factor |
| UniProt Synonym Protein Names: | Apurinic-apyrimidinic endonuclease APLF; PNK and APTX-like FHA domain-containing protein; XRCC1-interacting protein 1 |
| Protein Family: | Aprataxin and PNK-like factor |
| UniProt Gene Name: | APLF |
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