Metabolism Antibodies 2
Anti-APIP Antibody (CAB7102)
- SKU:
- CAB7102
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-APIP Antibody |
| Antibody SKU: | CAB7102 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human APIP (NP_057041.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 22Rv1, Mouse pancreas, Mouse stomach, Mouse heart, Mouse liver, Rat stomach |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human APIP (NP_057041.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSGC DARE GDCC SRRC GAQD KEHP RYLI PELC KQFY HLGW VTGT GGGI SLKH GDEI YIAP SGVQ KERI QPED MFVC DINE KDIS GPSP SKKL KKSQ CTPL FMNA YTMR GAGA VIHT HSKA AVMA TLLF PGRE FKIT HQEM IKGI KKCT SGGY YRYD DMLV VPII ENTP EEKD LKDR MAHA MNEY PDSC AVLV RRHG VYVW GETW EKAK TMCE CYDY LFDI AVSM KKVG LDPS QLPV GENG IV |
| Gene ID: | 51074 |
| Uniprot: | Q96GX9 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 22kDa/27kDa |
| Observed MW: | 27kDa |
| Synonyms: | APIP, APIP2, CGI-29, CGI29, MMRP19, hAPIP |
| Background: | APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008] |
| UniProt Protein Function: | MMRP19: Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c- dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 4.2.1.109; Amino Acid Metabolism - cysteine and methionine; Apoptosis Chromosomal Location of Human Ortholog: 11p13 Cellular Component: cytoplasm Molecular Function:identical protein binding; 5-methylthioribulose-1-phosphate 4-dehydratase activity; protein binding; zinc ion binding Biological Process: methionine salvage; sulfur amino acid metabolic process; apoptosis; methionine biosynthetic process from S-adenosylmethionine; polyamine metabolic process; negative regulation of apoptosis |
| NCBI Summary: | APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008] |
| UniProt Code: | Q96GX9 |
| NCBI GenInfo Identifier: | 74731866 |
| NCBI Gene ID: | 51074 |
| NCBI Accession: | Q96GX9.1 |
| UniProt Secondary Accession: | Q96GX9,Q6PJX6, Q8WVU2, Q96HK2, Q9Y318, A8K9D3, |
| UniProt Related Accession: | Q96GX9 |
| Molecular Weight: | 242 |
| NCBI Full Name: | Methylthioribulose-1-phosphate dehydratase |
| NCBI Synonym Full Names: | APAF1 interacting protein |
| NCBI Official Symbol: | APIP |
| NCBI Official Synonym Symbols: | APIP2; CGI29; hAPIP; CGI-29; MMRP19 |
| NCBI Protein Information: | methylthioribulose-1-phosphate dehydratase; APIP; MTRu-1-P dehydratase; APAF1-interacting protein; probable methylthioribulose-1-phosphate dehydratase |
| UniProt Protein Name: | Methylthioribulose-1-phosphate dehydratase |
| UniProt Synonym Protein Names: | APAF1-interacting protein |
| UniProt Gene Name: | APIP |
| UniProt Entry Name: | MTNB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using APIP antibody (CAB7102) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human colon using APIP Rabbit pAb (CAB7102) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse liver using APIP Rabbit pAb (CAB7102) at dilution of 1:100 (40x lens). |
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