Cell Biology Antibodies 15

Anti-APH1B Antibody (CAB17784)

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SKU:
CAB17784
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-APH1B Antibody
Antibody SKU:CAB17784
Antibody Size:20uL, 50 uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human APH1B (NP_112591.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human APH1B (NP_112591.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GLKS INPG ETAP SMRL LAYV SGLG FGIM SGVF SFVN TLSD SLGP GTVG IHGD SPQF FLYS AFMT LVII LLHV FWGI VFFD GCEK KKWG ILLI VLLT HLLV SAQT FISS YYGI NLAS AFII LVLM GTWA FLAA GGSC RSLK LCLL CQDK NFLL YNQR SR
Gene ID:83464
Uniprot:Q8WW43
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:APH-1B, PRO1328, PSFL, TAAV688, APH1B
Background:This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
UniProt Protein Function:APH1B: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. Belongs to the APH-1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q22.2

Cellular Component: integral to membrane; plasma membrane; transport vesicle

Molecular Function:peptidase activity; protein binding

Biological Process: ephrin receptor signaling pathway; membrane protein intracellular domain proteolysis; Notch receptor processing; Notch signaling pathway; positive regulation of apoptosis; positive regulation of catalytic activity; protein processing

NCBI Summary:This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
UniProt Code:Q8WW43
NCBI GenInfo Identifier:61252592
NCBI Gene ID:83464
NCBI Accession:Q8WW43.3
UniProt Secondary Accession:Q8WW43,Q564N3, Q6UWQ1, Q9H0S0, A8K589,
UniProt Related Accession:Q8WW43
Molecular Weight:24,282 Da
NCBI Full Name:Gamma-secretase subunit APH-1B
NCBI Synonym Full Names:aph-1 homolog B, gamma-secretase subunit
NCBI Official Symbol:APH1B  
NCBI Official Synonym Symbols:PSFL; APH-1B; PRO1328; TAAV688  
NCBI Protein Information:gamma-secretase subunit APH-1B
UniProt Protein Name:Gamma-secretase subunit APH-1B
UniProt Synonym Protein Names:Aph-1beta; Presenilin-stabilization factor-like
Protein Family:Gamma-secretase
UniProt Gene Name:APH1B  
UniProt Entry Name:APH1B_HUMAN
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