Cell Biology Antibodies 8

Anti-APCS Antibody (CAB1996)

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SKU:
CAB1996
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-APCS Antibody
Antibody SKU:CAB1996
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-223 of human APCS (NP_001630.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-223 of human APCS (NP_001630.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNKP LLWI SVLT SLLE AFAH TDLS GKVF VFPR ESVT DHVN LITP LEKP LQNF TLCF RAYS DLSR AYSL FSYN TQGR DNEL LVYK ERVG EYSL YIGR HKVT SKVI EKFP APVH ICVS WESS SGIA EFWI NGTP LVKK GLRQ GYFV EAQP KIVL GQEQ DSYG GKFD RSQS FVGE IGDL YMWD SVLP PENI LSAY QGTP LPAN ILDW QALN YEIR GYVI IKPL VWV
Gene ID:325
Uniprot:P02743
Cellular Location:Secreted
Calculated MW:25kDa
Observed MW:30kDa
Synonyms:APCS, HEL-S-92n, PTX2, SAP
Background:The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
UniProt Protein Function:APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Chaperone

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; protein complex; extracellular region; nucleus

Molecular Function:complement component C1q binding; unfolded protein binding; virion binding; calcium ion binding; carbohydrate binding

Biological Process: protein folding; negative regulation of virion penetration into host cell; negative regulation of acute inflammatory response; acute-phase response; innate immune response; negative regulation of monocyte differentiation; chaperone-mediated protein complex assembly; negative regulation of viral reproduction

NCBI Summary:The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
UniProt Code:P02743
NCBI GenInfo Identifier:730704
NCBI Gene ID:325
NCBI Accession:P02743.2
UniProt Related Accession:P02743
Molecular Weight:223
NCBI Full Name:Serum amyloid P-component
NCBI Synonym Full Names:amyloid P component, serum
NCBI Official Symbol:APCS  
NCBI Official Synonym Symbols:SAP; PTX2; HEL-S-92n  
NCBI Protein Information:serum amyloid P-component; pentaxin-related; 9.5S alpha-1-glycoprotein; epididymis secretory sperm binding protein Li 92n
UniProt Protein Name:Serum amyloid P-component
UniProt Synonym Protein Names:9.5S alpha-1-glycoproteinSerum amyloid P-component(1-203)
UniProt Gene Name:APCS  
UniProt Entry Name:SAMP_HUMAN
Anti-APCS Antibody (CAB1996)Western blot analysis of extracts of 293T cells, using APCS antibody (CAB1996) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 50s.
Anti-APCS Antibody (CAB1996)Immunohistochemistry of paraffin-embedded rat spleen using APCS antibody (CAB1996) at dilution of 1:100 (40x lens).
Anti-APCS Antibody (CAB1996)Immunohistochemistry of paraffin-embedded mouse liver using APCS antibody (CAB1996) at dilution of 1:100 (40x lens).
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