Immunology Antibodies 3
Anti-AP1M1 Antibody (CAB17041)
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- SKU:
- CAB17041
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-AP1M1 Antibody |
| Antibody SKU: | CAB17041 |
| Antibody Size: | 20uL, 50 uL |
| Application: | IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human AP1M1 (NP_115882.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human AP1M1 (NP_115882.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSAS AVYV LDLK GKVL ICRN YRGD VDMS EVEH FMPI LMEK EEEG MLSP ILAH GGVR FMWI KHNN LYLV ATSK KNAC VSLV FSFL YKVV QVFS EYFK ELEE ESIR DNFV IIYE LLDE LMDF GYPQ TTDS KILQ EYIT QEGH KLET GAPR PPAT VTNA VSWR |
| Gene ID: | 8907 |
| Uniprot: | Q9BXS5 |
| Cellular Location: | |
| Calculated MW: | 48kDa/49kDa |
| Observed MW: | Refer to figures |
| Synonyms: | AP1M1, AP47, CLAPM2, CLTNM, MU-1A |
| Background: | The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. |
| UniProt Protein Function: | AP1M1: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes medium subunit family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 19p13.12 Cellular Component: cytoplasmic vesicle membrane; cytosol; Golgi membrane; lysosomal membrane; membrane; trans-Golgi network membrane Molecular Function:protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; melanosome organization and biogenesis; regulation of defense response to virus by virus |
| NCBI Summary: | The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BXS5 |
| NCBI GenInfo Identifier: | 18202738 |
| NCBI Gene ID: | 8907 |
| NCBI Accession: | Q9BXS5.3 |
| UniProt Secondary Accession: | Q9BXS5,Q4TTY5, |
| UniProt Related Accession: | Q9BXS5 |
| Molecular Weight: | 49,840 Da |
| NCBI Full Name: | AP-1 complex subunit mu-1 |
| NCBI Synonym Full Names: | adaptor related protein complex 1 mu 1 subunit |
| NCBI Official Symbol: | AP1M1 |
| NCBI Official Synonym Symbols: | AP47; CLTNM; MU-1A; CLAPM2 |
| NCBI Protein Information: | AP-1 complex subunit mu-1 |
| UniProt Protein Name: | AP-1 complex subunit mu-1 |
| UniProt Synonym Protein Names: | AP-mu chain family member mu1A; Adaptor protein complex AP-1 subunit mu-1; Adaptor-related protein complex 1 subunit mu-1; Clathrin assembly protein complex 1 mu-1 medium chain 1; Clathrin coat assembly protein AP47; Clathrin coat-associated protein AP47; Golgi adaptor HA1/AP1 adaptin mu-1 subunit; Mu-adaptin 1; Mu1A-adaptin |
| Protein Family: | AP-1 complex |
| UniProt Gene Name: | AP1M1 |
| UniProt Entry Name: | AP1M1_HUMAN |
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