Cell Biology Antibodies 8
Anti-AOC3 Antibody (CAB2001)
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- SKU:
- CAB2001
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-AOC3 Antibody |
| Antibody SKU: | CAB2001 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-190 of human AOC3 (NP_003725.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney, Mouse liver, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-190 of human AOC3 (NP_003725.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GRGG DGGE PSQL PHCP SVSP SAQP WTHP GQSQ LFAD LSRE ELTA VMRF LTQR LGPG LVDA AQAR PSDN CVFS VELQ LPPK AAAL AHLD RGSP PPAR EALA IVFF GRQP QPNV SELV VGPL PHPS YMRD VTVE RHGG PLPY HRRP VLFQ EYLD IDQM IFNR ELPQ |
| Gene ID: | 8639 |
| Uniprot: | Q16853 |
| Cellular Location: | Cell membrane, Single-pass type II membrane protein |
| Calculated MW: | 24kDa/70kDa/84kDa |
| Observed MW: | 95kDa |
| Synonyms: | AOC3, HPAO, SSAO, VAP-1, VAP1 |
| Background: | This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | AOC3: Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis. Belongs to the copper/topaquinone oxidase family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Oxidoreductase; Amino Acid Metabolism - phenylalanine; Other Amino Acids Metabolism - beta-alanine; Membrane protein, integral; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - glycine, serine and threonine; EC 1.4.3.21 Chromosomal Location of Human Ortholog: 17q21 Cellular Component: cell surface; microvillus; cytoplasm; plasma membrane; integral to membrane Molecular Function:amine oxidase activity; protein binding; protein homodimerization activity; copper ion binding; protein heterodimerization activity; cation channel activity; calcium ion binding; quinone binding Biological Process: response to antibiotic; amine metabolic process; cell adhesion; inflammatory response; cation transport |
| NCBI Summary: | This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] |
| UniProt Code: | Q16853 |
| NCBI GenInfo Identifier: | 2501336 |
| NCBI Gene ID: | 8639 |
| NCBI Accession: | Q16853.3 |
| UniProt Related Accession: | Q16853 |
| Molecular Weight: | Molecular Mass: 108.5kDaActual Protein Molecular Mass: 120kDa |
| NCBI Full Name: | Membrane primary amine oxidase |
| NCBI Synonym Full Names: | amine oxidase copper containing 3 |
| NCBI Official Symbol: | AOC3 |
| NCBI Official Synonym Symbols: | HPAO; SSAO; VAP1; VAP-1 |
| NCBI Protein Information: | membrane primary amine oxidase |
| UniProt Protein Name: | Membrane primary amine oxidase |
| UniProt Synonym Protein Names: | Copper amine oxidase; HPAO; Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1 |
| Protein Family: | Membrane primary amine oxidase |
| UniProt Gene Name: | AOC3 |
| UniProt Entry Name: | AOC3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AOC3 antibody (CAB2001) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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