KO Validated Antibodies 1

Anti-ANXA6 Antibody (CAB18069)[KO Validated]

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SKU:
CAB18069
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ANXA6 Antibody [KO Validated]
Antibody SKU:CAB18069
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ANXA6 (NP_001146.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ANXA6 (NP_001146.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAKP AQGA KYRG SIHD FPGF DPNQ DAEA LYTA MKGF GSDK EAIL DIIT SRSN RQRQ EVCQ SYKS LYGK DLIA DLKY ELTG KFER LIVG LMRP PAYC DAKE IKDA ISGI GTDE KCLI EILA SRTN EQMH QLVA AYKD AYER DLEA DIIG DTSG HFQK MLVV LLQG TREE DDVV SEDL VQQD VQDL YEAG ELKW GTDE AQFI YILG NRSK QHLR LVFD EYLK TTGK PIEA SIRG ELSG DFEK LMLA VVKC IR
Gene ID:309
Uniprot:P08133
Cellular Location:Cytoplasm, Melanosome
Calculated MW:72kDa/75kDa
Observed MW:76kDa
Anti-ANXA6 Antibody [KO Validated] (CAB18069)Western blot analysis of extracts from normal (control) and ANXA6 knockout (KO) HeLa cells, using ANXA6 antibody (CAB18069) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:ANXA6, ANX6, CBP68
Background:Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described.
NCBI Summary:Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
UniProt Code:P08133
NCBI GenInfo Identifier:71773329
NCBI Gene ID:309
NCBI Accession:NP_001146.2
UniProt Secondary Accession:P08133,Q6ZT79, B7Z8A7, D3DQH4, E9PGK1,
UniProt Related Accession:P08133
Molecular Weight:75,873 Da
NCBI Full Name:annexin A6 isoform 1
NCBI Synonym Full Names:annexin A6
NCBI Official Symbol:ANXA6  
NCBI Official Synonym Symbols:ANX6; CBP68  
NCBI Protein Information:annexin A6; p68; p70; CPB-II; annexin-6; calelectrin; lipocortin VI; calphobindin II; calphobindin-II; chromobindin-20; annexin VI (p68); 67 kDa calelectrin; calcium-binding protein p68
UniProt Protein Name:
UniProt Gene Name:
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