Anti-ANPRB/NRP2 Antibody (CAB19255)
- SKU:
- CAB19255
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NPR2
- Synonyms:
- AMDM
- Synonyms:
- ANPRB
- Synonyms:
- ANPb
- Synonyms:
- ECDM
- Synonyms:
- GUC2B
- Synonyms:
- GUCY2B
- Synonyms:
- NPRB
- Synonyms:
- NPRBi
- Synonyms:
- SNSK
- Synonyms:
- natriuretic peptide receptor 2
- Research Area:
- Metabolism
Description
| Product Name: | ANPRB/NRP2 Rabbit mAb |
| Product Code: | CAB19255 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | NPR2, AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK, natriuretic peptide receptor 2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human ANPRB/NRP2. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung, Mouse spleen |
| Immunogen: | Recombinant protein of human ANPRB/NRP2. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4882 |
| Uniprot: | P20594 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 117kDa |
| Observed MW: | 130KDa |
| UniProt Protein Function: | ANPB: natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. 21 mutations linked to acromesomelic dysplasia (skeletal malformation). 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, protein; Membrane protein, integral; Lyase; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Nucleotide Metabolism - purine; EC 4.6.1.2; Receptor, misc.; Guanylyl cyclase; RGC group; RGC family Chromosomal Location of Human Ortholog: 9p21-p12 Cellular Component: guanylate cyclase complex, soluble; integral to membrane; plasma membrane Molecular Function:adenylate cyclase activity; ATP binding; GTP binding; guanylate cyclase activity; hormone binding; identical protein binding; natriuretic peptide receptor activity; peptide hormone binding; protein kinase activity; receptor activity; transmembrane receptor activity Biological Process: cell surface receptor linked signal transduction; cGMP biosynthetic process; negative regulation of meiotic cell cycle; ossification; protein amino acid phosphorylation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; signal transduction Disease: Acromesomelic Dysplasia, Maroteaux Type; Epiphyseal Chondrodysplasia, Miura Type; Short Stature With Nonspecific Skeletal Abnormalities |
| NCBI Summary: | This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20594 |
| NCBI GenInfo Identifier: | 113916 |
| NCBI Gene ID: | 4882 |
| NCBI Accession: | P20594.1 |
| UniProt Secondary Accession: | P20594,O60871, Q4VAK7, Q5TCV2, Q8TA93, Q9UQ50, B0ZBF2 B0ZBF3, D3DRP3, D3DRP4, |
| UniProt Related Accession: | P20594 |
| Molecular Weight: | 111,208 Da |
| NCBI Full Name: | Atrial natriuretic peptide receptor 2 |
| NCBI Synonym Full Names: | natriuretic peptide receptor 2 |
| NCBI Official Symbol: | NPR2 |
| NCBI Official Synonym Symbols: | AMDM; ANPb; ECDM; NPRB; SNSK; ANPRB; GUC2B; NPRBi; GUCY2B |
| NCBI Protein Information: | atrial natriuretic peptide receptor 2 |
| UniProt Protein Name: | Atrial natriuretic peptide receptor 2 |
| UniProt Synonym Protein Names: | Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B; GC-B |
| UniProt Gene Name: | NPR2 |
| UniProt Entry Name: | ANPRB_HUMAN |
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