Signal Transduction Antibodies 1
Anti-ANO6 Antibody (CAB12050)
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- SKU:
- CAB12050
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-ANO6 Antibody |
| Antibody SKU: | CAB12050 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-830 of human ANO6 (NP_001020527.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Mouse liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 750-830 of human ANO6 (NP_001020527.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IPRL VYYW SFSV PPYG DHTS YTME GYIN NTLS IFKV ADFK NKSK GNPY SDLG NHTT CRYR DFRY PPGH PQEY KHNI YYWH V |
| Gene ID: | 196527 |
| Uniprot: | Q4KMQ2 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 103kDa/106kDa/108kDa |
| Observed MW: | 110kDa |
| Synonyms: | ANO6, BDPLT7, SCTS, TMEM16F |
| Background: | This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. |
| NCBI Summary: | This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
| UniProt Code: | Q4KMQ2 |
| NCBI GenInfo Identifier: | 218156299 |
| NCBI Gene ID: | 196527 |
| NCBI Accession: | NP_001020527.2 |
| UniProt Secondary Accession: | Q4KMQ2,Q8N3Q2, A6NNM6, B9EGG0, E7ENK4, E9PB30, E9PCT2 |
| UniProt Related Accession: | Q4KMQ2 |
| Molecular Weight: | 108,102 Da |
| NCBI Full Name: | anoctamin-6 isoform a |
| NCBI Synonym Full Names: | anoctamin 6 |
| NCBI Official Symbol: | ANO6 |
| NCBI Official Synonym Symbols: | SCTS; BDPLT7; TMEM16F |
| NCBI Protein Information: | anoctamin-6 |
| UniProt Protein Name: | Anoctamin-6 |
| UniProt Synonym Protein Names: | Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F |
| Protein Family: | Anoctamin |
| UniProt Gene Name: | ANO6 |
 | Western blot analysis of extracts of various cell lines, using ANO6 antibody (CAB12050) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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