Cell Cycle Antibodies 1
Anti-ANLN Antibody (CAB6524)
- SKU:
- CAB6524
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-ANLN Antibody |
| Antibody SKU: | CAB6524 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 845-1124 of human ANLN (NP_061155.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Rat |
| Positive Samples: | 293T, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 845-1124 of human ANLN (NP_061155.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ATPL ASTS NSLN GDAL TFTT TFTL QDVS NDFE INIE VYSL VQKK DPSG LDKK KKTS KSKA ITPK RLLT SITT KSNI HSSV MASP GGLS AVRT SNFA LVGS YTLS LSSV GNTK FVLD KVPF LSSL EGHI YLKI KCQV NSSV EERG FLTI FEDV SGFG AWHR RWCV LSGN CISY WTYP DDEK RKNP IGRI NLAN CTSR QIEP ANRE FCAR RNTF ELIT VRPQ REDD RETL VSQC RDTL CVTK NWLS ADTK EERD LWMQ KLNQ VLVD IRLW QPDA CYKP IGKP |
| Gene ID: | 54443 |
| Uniprot: | Q9NQW6 |
| Cellular Location: | Cytoplasm, Nucleus, cell cortex, cytoskeleton |
| Calculated MW: | 120kDa/124kDa |
| Observed MW: | 120kDa |
| Synonyms: | ANLN, FSGS8, Scraps, scra, anillin |
| Background: | This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | anillin: an actin binding protein that interacts with cleavage furrow proteins such as septins and may play a role in cytokinesis. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 7p15-p14 Cellular Component: nucleoplasm; intracellular membrane-bound organelle; contractile ring; actin cytoskeleton Molecular Function:actin binding Biological Process: mitosis; cytokinesis after mitosis; septin ring assembly; regulation of exit from mitosis; hemopoietic progenitor cell differentiation Disease: Focal Segmental Glomerulosclerosis 8 |
| NCBI Summary: | This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] |
| UniProt Code: | Q9NQW6 |
| NCBI GenInfo Identifier: | 90111962 |
| NCBI Gene ID: | 54443 |
| NCBI Accession: | Q9NQW6.2 |
| UniProt Secondary Accession: | Q9NQW6,Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0, |
| UniProt Related Accession: | Q9NQW6 |
| Molecular Weight: | 1124 |
| NCBI Full Name: | Actin-binding protein anillin |
| NCBI Synonym Full Names: | anillin, actin binding protein |
| NCBI Official Symbol: | ANLN |
| NCBI Official Synonym Symbols: | scra; FSGS8; Scraps |
| NCBI Protein Information: | actin-binding protein anillin |
| UniProt Protein Name: | Actin-binding protein anillin |
| Protein Family: | Anillin |
| UniProt Gene Name: | ANLN |
| UniProt Entry Name: | ANLN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ANLN antibody (CAB6524) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of A549 cells using ANLN antibody (CAB6524). |
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