Cell Biology Antibodies 6

Anti-ANKK1 Antibody (CAB16178)

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SKU:
CAB16178
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ANKK1 Antibody
Antibody SKU:CAB16178
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ANKK1 (NP_848605.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ANKK1 (NP_848605.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAD PTEL RLGS LPVF TRDD FEGD WRLV ASGG FSQV FQAR HRRW RTEY AIKC APCL PPDA ASSD VNYL IEEA AKMK KIKF QHIV SIYG VCKQ PLGI VMEF MANG SLEK VLST HSLC WKLR FRII HETS LAMN FLHS IKPP LLHL DLKP GNIL LDSN MHVK ISDF GLSK WMEQ STRM QYIE RSAL RGML SYIP PEMF LESN KAPG PKYD VYSF AIVI WELL TQKK PYSG FNMM MIII RVAA GMRP SLQP VSDQ WPSE AQQM VDLM KRCW DQDP KKRP CFLD ITIE TDIL LSLL QSRV AVPE
Gene ID:255239
Uniprot:Q8NFD2
Cellular Location:
Calculated MW:84kDa
Observed MW:85kDa
Synonyms:ANKK1, PKK2
Background:The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP.
UniProt Protein Function:ANKK1: belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]
UniProt Protein Details:

Protein type:Protein kinase, TKL; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); TKL group; RIPK family

Chromosomal Location of Human Ortholog: 11q23.2

Molecular Function:protein serine/threonine kinase activity; ATP binding

Biological Process: protein amino acid phosphorylation

NCBI Summary:The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]
UniProt Code:Q8NFD2
NCBI GenInfo Identifier:30425444
NCBI Gene ID:255239
NCBI Accession:NP_848605.1
UniProt Related Accession:Q8NFD2
Molecular Weight:84,632 Da
NCBI Full Name:ankyrin repeat and protein kinase domain-containing protein 1
NCBI Synonym Full Names:ankyrin repeat and kinase domain containing 1
NCBI Official Symbol:ANKK1  
NCBI Official Synonym Symbols:PKK2  
NCBI Protein Information:ankyrin repeat and protein kinase domain-containing protein 1; sgK288; X-kinase; sugen kinase 288; protein kinase PKK2
UniProt Protein Name:Ankyrin repeat and protein kinase domain-containing protein 1
UniProt Synonym Protein Names:Protein kinase PKK2; Sugen kinase 288; SgK288; X-kinase
Protein Family:Ankyrin repeat and protein kinase domain-containing protein
UniProt Gene Name:ANKK1  
UniProt Entry Name:ANKK1_HUMAN
Anti-ANKK1 Antibody (CAB16178)Western blot analysis of extracts of U-87MG cells, using ANKK1 antibody (CAB16178) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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