Antibody Name:	Anti-ANKHD1 Antibody
Antibody SKU:	CAB14902
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1620-1800 of human ANKHD1 (NP_060217.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1620-1800 of human ANKHD1 (NP_060217.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	VNSS KYPS LLLH SQEE KTST ATSK TQTR LEGE VTPN SLST SYKT VSLP LSSP NIKL NLTS PKRG QKRE EGWK EVVR RSKK LSVP ASVV SRIM GRGG CNIT AIQD VTGA HIDV DKQK DKNG ERMI TIRG GTES TRYA VQLI NALI QDPA KELE DLIP KNHI RTPA STKS IHAN FSSG VGTT A
Gene ID:	54882
Uniprot:	Q8IWZ3
Cellular Location:	Cytoplasm
Calculated MW:	59kDa/63kDa/64kDa/269kDa/277kDa
Observed MW:	Refer to figures

Synonyms:

ANKHD1, MASK, MASK1, PP2500, VBARP

Background:

This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.

UniProt Protein Function:	ANKHD1: May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. Belongs to the mask family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:RNA-binding; Apoptosis Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: cytoplasm Molecular Function:protein binding
NCBI Summary:	This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Sep 2010]
UniProt Code:	Q8IWZ3
NCBI GenInfo Identifier:	74750718
NCBI Gene ID:	54882
NCBI Accession:	Q8IWZ3.1
UniProt Secondary Accession:	Q8IWZ3,Q149P2, Q8IWZ2, Q8WY90, Q96G77, Q96GK0, Q9H2U0 Q9HA95, Q9NWG4, Q9UPR7, A6NH85,
UniProt Related Accession:	Q8IWZ3
Molecular Weight:	277,175 Da
NCBI Full Name:	Ankyrin repeat and KH domain-containing protein 1
NCBI Synonym Full Names:	ankyrin repeat and KH domain containing 1
NCBI Official Symbol:	ANKHD1
NCBI Official Synonym Symbols:	MASK; VBARP; PP2500
NCBI Protein Information:	ankyrin repeat and KH domain-containing protein 1; HIV-1 Vpr-binding ankyrin repeat protein; multiple ankyrin repeats, single KH-domain homolog
UniProt Protein Name:	Ankyrin repeat and KH domain-containing protein 1
UniProt Synonym Protein Names:	HIV-1 Vpr-binding ankyrin repeat protein; Multiple ankyrin repeats single KH domain; hMASK
Protein Family:	Ankyrin repeat and KH domain-containing protein
UniProt Gene Name:	ANKHD1
UniProt Entry Name:	ANKH1_HUMAN