Name: Anti-ANGPT4 Antibody (CAB10589)
Brand: Cell Biology Antibodies 16
SKU: CAB10589
Availability: OutOfStock

Antibody Name:	Anti-ANGPT4 Antibody
Antibody SKU:	CAB10589
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 25-260 of human ANGPT4 (NP_057069.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	HeLa

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 25-260 of human ANGPT4 (NP_057069.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	TRQE ADRG CETL VVQH GHCS YTFL LPKS EPCP PGPE VSRD SNTL QRES LANP LHLG KLPT QQVK QLEQ ALQN NTQW LKKL ERAI KTIL RSKL EQVQ QQMA QNQT APML ELGT SLLN QTTA QIRK LTDM EAQL LNQT SRMD AQMP ETFL STNK LENQ LLLQ RQKL QQLQ GQNS ALEK RLQA LETK QQEE LASI LSKK AKLL NTLS RQSA ALTN IERG LRGV RHNS SLLQ DQQH SLRQ
Gene ID:	51378
Uniprot:	Q9Y264
Cellular Location:	Secreted
Calculated MW:	46kDa/56kDa
Observed MW:	57kDa

Western blot - ANGPT4 Polyclonal Antibody (CAB10589)

Synonyms:

ANGPT4, ANG3, ANG4

Background:

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin.

UniProt Protein Function:	ANGPT4: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
UniProt Protein Details:	Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 20p13 Cellular Component: extracellular space; extracellular region Molecular Function:transmembrane receptor protein tyrosine kinase activator activity; receptor tyrosine kinase binding Biological Process: positive regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of angiogenesis; transmembrane receptor protein tyrosine kinase activation (dimerization); endothelial cell proliferation; positive regulation of blood vessel endothelial cell migration; angiogenesis; negative regulation of blood vessel endothelial cell migration; blood coagulation; leukocyte migration; negative regulation of apoptosis
NCBI Summary:	Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9Y264
NCBI GenInfo Identifier:	7705276
NCBI Gene ID:	51378
NCBI Accession:	NP_057069.1
UniProt Secondary Accession:	Q9Y264,Q5TFF4, Q9H4Z4,
UniProt Related Accession:	Q9Y264
Molecular Weight:	56,849 Da
NCBI Full Name:	angiopoietin-4
NCBI Synonym Full Names:	angiopoietin 4
NCBI Official Symbol:	ANGPT4
NCBI Official Synonym Symbols:	AGP4; ANG4; ANG-3
NCBI Protein Information:	angiopoietin-4; ANG-4; angiopoietin-3; dJ824F16.2 (angiopoietin 4)
UniProt Protein Name:	Angiopoietin-4
UniProt Synonym Protein Names:	Angiopoietin-3
Protein Family:	Angiogenin
UniProt Gene Name:	ANGPT4
UniProt Entry Name:	ANGP4_HUMAN