Cell Cycle Antibodies 2

Anti-ANAPC13 Antibody (CAB9967)

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SKU:
CAB9967
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-ANAPC13 Antibody
Antibody SKU:CAB9967
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-74 of human ANAPC13 (NP_056206.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, MCF7, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-74 of human ANAPC13 (NP_056206.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDSE VQRD GRIL DLID DAWR EDKL PYED VAIP LNEL PEPE QDNG GTTE SVKE QEMK WTDL ALQY LHEN VPPI GN
Gene ID:25847
Uniprot:Q9BS18
Cellular Location:Nucleus
Calculated MW:8kDa
Observed MW:15kDa
Synonyms:ANAPC13, APC13, SWM1
Background:This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined.
UniProt Protein Function:APC13: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC13 family.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3q22.2

Cellular Component: anaphase-promoting complex

Biological Process: mitosis; cell division

NCBI Summary:This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
UniProt Code:Q9BS18
NCBI GenInfo Identifier:74732956
NCBI Gene ID:25847
NCBI Accession:Q9BS18.1
UniProt Secondary Accession:Q9BS18,Q9Y3V0,
UniProt Related Accession:Q9BS18
Molecular Weight:8,521 Da
NCBI Full Name:Anaphase-promoting complex subunit 13
NCBI Synonym Full Names:anaphase promoting complex subunit 13
NCBI Official Symbol:ANAPC13  
NCBI Official Synonym Symbols:SWM1; APC13  
NCBI Protein Information:anaphase-promoting complex subunit 13; cyclosome subunit 13
UniProt Protein Name:Anaphase-promoting complex subunit 13
UniProt Synonym Protein Names:Cyclosome subunit 13
UniProt Gene Name:ANAPC13  
UniProt Entry Name:APC13_HUMAN
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