Cell Biology Antibodies 5
Anti-AMICA1 Antibody (CAB14958)
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- SKU:
- CAB14958
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-AMICA1 Antibody |
| Antibody SKU: | CAB14958 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 285-384 of human AMICA1 (NP_694938.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 285-384 of human AMICA1 (NP_694938.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IVKK TCGN KSSV NSTV LVKN TKKT NPEI KEKP CHFE RCEG EKHI YSPI IVRE VIEE EEPS EKSE ATYM TMHP VWPS LRSD RNNS LEKK SGGG MPKT QQAF |
| Gene ID: | 120425 |
| Uniprot: | Q86YT9 |
| Cellular Location: | Cell junction, Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 29kDa/40kDa/43kDa/44kDa |
| Observed MW: | Refer to figures |
| Synonyms: | JAML, AMICA, AMICA1, CREA7-1, CREA7-4, Gm638 |
| Background: |
| UniProt Protein Function: | AMICA1: an adhesion molecule that may function in the migration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells. Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: plasma membrane; tight junction Molecular Function:cell adhesion molecule binding; integrin binding; protein homodimerization activity Biological Process: gamma-delta T cell activation; heterophilic cell adhesion; leukocyte migration; neutrophil chemotaxis; positive regulation of epithelial cell proliferation involved in wound healing; regulation of immune response |
| UniProt Code: | Q86YT9 |
| NCBI GenInfo Identifier: | 71151910 |
| NCBI Gene ID: | 120425 |
| NCBI Accession: | Q86YT9.1 |
| UniProt Secondary Accession: | Q86YT9,Q496M1, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70, B0YIV1 B0YIV2, |
| UniProt Related Accession: | Q86YT9 |
| Molecular Weight: | 40,136 Da |
| NCBI Full Name: | Junctional adhesion molecule-like |
| NCBI Synonym Full Names: | junction adhesion molecule like |
| NCBI Official Symbol: | JAML |
| NCBI Official Synonym Symbols: | AMICA; Gm638; AMICA1; CREA7-1; CREA7-4 |
| NCBI Protein Information: | junctional adhesion molecule-like |
| UniProt Protein Name: | Junctional adhesion molecule-like |
| UniProt Synonym Protein Names: | Adhesion molecule interacting with CXADR antigen 1; Dendritic cell-specific protein CREA7-1 |
| UniProt Gene Name: | JAML |
| UniProt Entry Name: | JAML_HUMAN |
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