Cell Biology Antibodies 18
Anti-AMELX Antibody (CAB18337)
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- SKU:
- CAB18337
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-AMELX Antibody |
| Antibody SKU: | CAB18337 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human AMELX. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant protein of human AMELX. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 265 |
| Uniprot: | Q99217 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | AI1E, AIH1, ALGN, AMG, AMGL, AMGX, AMELX |
| Background: |
| UniProt Protein Function: | AMELX: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Defects in AMELX are the cause of amelogenesis imperfecta type 1E (AI1E). A X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small. Belongs to the amelogenin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xp22.31-p22.1 Cellular Component: cell surface; proteinaceous extracellular matrix Molecular Function:growth factor activity; hydroxyapatite binding; identical protein binding; protein binding; structural constituent of tooth enamel Biological Process: biomineral formation; cell adhesion; cell proliferation; chondrocyte differentiation; epithelial to mesenchymal transition; ion homeostasis; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of collagen biosynthetic process; signal transduction Disease: Amelogenesis Imperfecta, Type Ie |
| NCBI Summary: | This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99217 |
| NCBI GenInfo Identifier: | 1168430 |
| NCBI Gene ID: | 265 |
| NCBI Accession: | Q99217.1 |
| UniProt Secondary Accession: | Q99217,Q96NW6, Q9UCA7, |
| UniProt Related Accession: | Q99217 |
| Molecular Weight: | 23,111 Da |
| NCBI Full Name: | Amelogenin, X isoform |
| NCBI Synonym Full Names: | amelogenin, X-linked |
| NCBI Official Symbol: | AMELX |
| NCBI Official Synonym Symbols: | AMG; AI1E; AIH1; ALGN; AMGL; AMGX |
| NCBI Protein Information: | amelogenin, X isoform |
| UniProt Protein Name: | Amelogenin, X isoform |
| Protein Family: | Amelogenin |
| UniProt Gene Name: | AMELX |
| UniProt Entry Name: | AMELX_HUMAN |
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