Cell Biology Antibodies 15
Anti-alpha smooth muscle Actin Antibody (CAB17910)
- SKU:
- CAB17910
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-alpha smooth muscle Actin Rabbit Monoclonal Antibody |
Antibody SKU: | CAB17910 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human alpha smooth muscle Actin |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | RD, Mouse large intestine, Mouse heart, Mouse brain, Rat lung, Rat heart |
Immunogen: | A synthesized peptide derived from human alpha smooth muscle Actin |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 59 |
Uniprot: | P62736 |
Cellular Location: | |
Calculated MW: | 42kDa |
Observed MW: | 42kDa |
Synonyms: | AAT6, ACTSA, MYMY5, ACTA2, actin |
Background: | The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008] |
UniProt Protein Function: | ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family. |
UniProt Protein Details: | Protein type:Contractile; Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10q23.3 Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton Molecular Function:protein kinase binding; ATP binding Biological Process: muscle contraction; response to virus; regulation of blood pressure; vascular smooth muscle contraction Disease: Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome; Aortic Aneurysm, Familial Thoracic 6 |
NCBI Summary: | The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008] |
UniProt Code: | P62736 |
NCBI GenInfo Identifier: | 51316972 |
NCBI Gene ID: | 59 |
NCBI Accession: | P62736.1 |
UniProt Secondary Accession: | P62736,P03996, P04108, Q6FI19, B2R8A4, |
UniProt Related Accession: | P62736 |
Molecular Weight: | 42,009 Da |
NCBI Full Name: | Actin, aortic smooth muscle |
NCBI Synonym Full Names: | actin, alpha 2, smooth muscle, aorta |
NCBI Official Symbol: | ACTA2 |
NCBI Official Synonym Symbols: | AAT6; ACTSA; MYMY5 |
NCBI Protein Information: | actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein |
UniProt Protein Name: | Actin, aortic smooth muscle |
UniProt Synonym Protein Names: | Alpha-actin-2; Cell growth-inhibiting gene 46 protein |
Protein Family: | Actin |
UniProt Gene Name: | ACTA2 |
UniProt Entry Name: | ACTA_HUMAN |