Anti-alpha-Actin-1 (ACTA1) Antibody (CAB2280)
- SKU:
- CAB2280
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ACTA
- Synonyms:
- ASMA
- Synonyms:
- CFTD
- Synonyms:
- CFTD1
- Synonyms:
- CFTDM
- Synonyms:
- MPFD
- Synonyms:
- NEM1
- Synonyms:
- NEM2
- Synonyms:
- NEM3
- Synonyms:
- SHPM
Description
| Product Name: | ?-Actin-1 (ACTA1) Rabbit mAb |
| Product Code: | CAB2280 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3, SHPM |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ?-Actin-1 (ACTA1) |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, A-431, C6, Mouse lung, Mouse brain, Mouse heart, Rat heart |
| Immunogen: | A synthesized peptide derived from human ?-Actin-1 (ACTA1) |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 58 |
| Uniprot: | P68133 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
| UniProt Protein Function: | ACTA1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells. Belongs to the actin family. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Motility/polarity/chemotaxis; Contractile; Cytoskeletal Chromosomal Location of Human Ortholog: 1q42.13 Cellular Component: extracellular space; sarcomere; stress fiber; actin filament; cytosol; striated muscle thin filament; actin cytoskeleton Molecular Function:protein binding; myosin binding; structural constituent of cytoskeleton; ADP binding; ATP binding Biological Process: skeletal muscle fiber adaptation; muscle contraction; muscle thin filament assembly; response to steroid hormone stimulus; response to mechanical stimulus; response to lithium ion; response to extracellular stimulus; skeletal muscle fiber development; cell growth; muscle filament sliding Disease: Nemaline Myopathy 3; Myopathy, Congenital, With Fiber-type Disproportion |
| NCBI Summary: | The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P68133 |
| NCBI GenInfo Identifier: | 4501881 |
| NCBI Gene ID: | 58 |
| NCBI Accession: | NP_001091.1 |
| UniProt Secondary Accession: | P68133,P02568, P99020, Q5T8M9, |
| UniProt Related Accession: | P68133 |
| Molecular Weight: | 42,051 Da |
| NCBI Full Name: | actin, alpha skeletal muscle |
| NCBI Synonym Full Names: | actin, alpha 1, skeletal muscle |
| NCBI Official Symbol: | ACTA1 |
| NCBI Official Synonym Symbols: | ACTA; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; CFTD1; CFTDM |
| NCBI Protein Information: | actin, alpha skeletal muscle; nemaline myopathy type 3 |
| UniProt Protein Name: | Actin, alpha skeletal muscle |
| UniProt Synonym Protein Names: | Alpha-actin-1 |
| UniProt Gene Name: | ACTA1 |
| UniProt Entry Name: | ACTS_HUMAN |
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