Immunology Antibodies 3
Anti-Alpha-2-antiplasmin Antibody (CAB9945)
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- SKU:
- CAB9945
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-Alpha-2-antiplasmin Antibody |
| Antibody SKU: | CAB9945 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 302-491 of human SERPINF2 (NP_001159392.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Rat |
| Positive Samples: | HepG2, A-549, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 302-491 of human SERPINF2 (NP_001159392.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VPTH FEWN VSQV LANL SWDT LHPP LVWE RPTK VRLP KLYL KHQM DLVA TLSQ LGLQ ELFQ APDL RGIS EQSL VVSG VQHQ STLE LSEV GVEA AAAT SIAM SRMS LSSF SVNR PFLF FIFE DTTG LPLF VGSV RNPN PSAP RELK EQQD SPGN KDFL QSLK GFPR GDKL FGPD LKLV PPME EDYP QFGS PK |
| Gene ID: | 5345 |
| Uniprot: | P08697 |
| Cellular Location: | Secreted |
| Calculated MW: | 47kDa/54kDa |
| Observed MW: | 65kDa |
| Synonyms: | SERPINF2, A2AP, AAP, ALPHA-2-PI, API, PLI |
| Background: | This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SERPINF2: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID). APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis. Belongs to the serpin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 17p13 Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein binding; protein homodimerization activity; protease binding; endopeptidase inhibitor activity Biological Process: platelet activation; collagen fibril organization; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; response to organic substance; fibrinolysis; negative regulation of fibrinolysis; platelet degranulation; renin-angiotensin regulation of blood vessel size; positive regulation of stress fiber formation; acute-phase response; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; positive regulation of cell differentiation Disease: Alpha-2-plasmin Inhibitor Deficiency |
| NCBI Summary: | This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P08697 |
| NCBI GenInfo Identifier: | 260064048 |
| NCBI Gene ID: | 5345 |
| NCBI Accession: | NP_001159392.1 |
| UniProt Secondary Accession: | P08697,Q8N5U7, Q9UCG2, Q9UCG3, B4E1B7, |
| UniProt Related Accession: | P08697 |
| Molecular Weight: | 47,907 Da |
| NCBI Full Name: | alpha-2-antiplasmin isoform a |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
| NCBI Official Symbol: | SERPINF2 |
| NCBI Official Synonym Symbols: | AAP; API; PLI; A2AP; ALPHA-2-PI |
| NCBI Protein Information: | alpha-2-antiplasmin; alpha-2-AP; alpha-2-plasmin inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; serpin F2 |
| UniProt Protein Name: | Alpha-2-antiplasmin |
| UniProt Synonym Protein Names: | Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2 |
| UniProt Gene Name: | SERPINF2 |
| UniProt Entry Name: | A2AP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SERPINF2 antibody (CAB9945) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat pancreas using SERPINF2 antibody (CAB9945) at dilution of 1:100 (40x lens). |
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