Cell Biology Antibodies 17

Anti-alpha 1 Spectrin Antibody (CAB9597)

(No reviews yet) Write a Review
SKU:
CAB9597
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-alpha 1 Spectrin Antibody
Antibody SKU:CAB9597
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human alpha 1 Spectrin
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:K-562, Mouse lung, Rat heart
Immunogen:A synthesized peptide derived from human alpha 1 Spectrin
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6708
Uniprot:P02549
Cellular Location:
Calculated MW:280kDa
Observed MW:280KDa
Synonyms:EL2, HPP, HS3, SPH3, SPTA
Background:Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
UniProt Protein Function:SPTA1: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in SPTA1 are the cause of elliptocytosis type 2 (EL2). EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP). HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells. Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3); also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive. Belongs to the spectrin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: spectrin; cytosol; actin cytoskeleton

Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton; protein heterodimerization activity; calcium ion binding

Biological Process: regulation of cell shape; axon guidance; positive regulation of protein binding; plasma membrane organization and biogenesis; actin filament capping; actin filament organization; positive regulation of T cell proliferation; hemopoiesis; lymphocyte homeostasis; porphyrin biosynthetic process

Disease: Elliptocytosis 2; Pyropoikilocytosis, Hereditary; Spherocytosis, Type 3

NCBI Summary:Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
UniProt Code:P02549
NCBI GenInfo Identifier:308153675
NCBI Gene ID:6708
NCBI Accession:P02549.5
UniProt Secondary Accession:P02549,Q15514, Q5VYL1, Q5VYL2, Q6LDY5,
UniProt Related Accession:P02549
Molecular Weight:279,674 Da
NCBI Full Name:Spectrin alpha chain, erythrocytic 1
NCBI Synonym Full Names:spectrin, alpha, erythrocytic 1
NCBI Official Symbol:SPTA1  
NCBI Official Synonym Symbols:EL2; HPP; HS3; SPH3; SPTA  
NCBI Protein Information:spectrin alpha chain, erythrocytic 1; alpha-I spectrin; elliptocytosis 2; erythroid alpha-spectrin; spectrin alpha chain, erythrocyte; spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
UniProt Protein Name:Spectrin alpha chain, erythrocytic 1
UniProt Synonym Protein Names:Erythroid alpha-spectrin
Protein Family:Spectrin
UniProt Gene Name:SPTA1  
UniProt Entry Name:SPTA1_HUMAN
Anti-alpha 1 Spectrin Antibody (CAB9597)Western blot - alpha 1 Spectrin Rabbit mAb (CAB9597)
View AllClose

0 Reviews

View AllClose

Related Products