Cell Biology Antibodies 7

Anti-ALG9 Antibody (CAB17213)

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SKU:
CAB17213
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ALG9 Antibody
Antibody SKU:CAB17213
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 439-618 of human ALG9 (NP_079016.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 439-618 of human ALG9 (NP_079016.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LFRG YHGP LDLY PEFY RIAT DPTI HTVP EGRP VNVC VGKE WYRF PSSF LLPD NWQL QFIP SEFR GQLP KPFA EGPL ATRI VPTD MNDQ NLEE PSRY IDIS KCHY LVDL DTMR ETPR EPKY SSNK EEWI SLAY RPFL DASR SSKL LRAF YVPF LSDQ YTVY VNYT ILKP RKAK QIRK KSGG
Gene ID:79796
Uniprot:Q9H6U8
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:ALG9, CDG1L, DIBD1, GIKANIS, LOH11CR1J, alpha-1
Background:This gene encodes an alpha-1, 2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:ALG9: Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. A chromosomal aberration involving ALG9 is found in a family with bipolar affective disorder. Translocation t(9;11)(p24;q23). However, common variations in ALG9 do not play a major role in predisposition to bipolar affective disorder. Defects in ALG9 are the cause of congenital disorder of glycosylation type 1L (CDG1L). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase 22 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.4.1.261; Transferase; Membrane protein, multi-pass; EC 2.4.1.259; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function:mannosyltransferase activity

Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification

Disease: Congenital Disorder Of Glycosylation, Type Il

NCBI Summary:This gene encodes an alpha-1,2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Code:Q9H6U8
NCBI GenInfo Identifier:118026933
NCBI Gene ID:79796
NCBI Accession:NP_001071158.1
UniProt Secondary Accession:Q9H6U8,Q6ZMD5, Q7Z4R4, Q96GS7, Q96PB9, Q9H068,
UniProt Related Accession:Q9H6U8
Molecular Weight:51,743 Da
NCBI Full Name:alpha-1,2-mannosyltransferase ALG9 isoform b
NCBI Synonym Full Names:ALG9, alpha-1,2-mannosyltransferase
NCBI Official Symbol:ALG9  
NCBI Official Synonym Symbols:CDG1L; DIBD1; LOH11CR1J  
NCBI Protein Information:alpha-1,2-mannosyltransferase ALG9; disrupted in bipolar disorder protein 1; disrupted in bipolar affective disorder 1; asparagine-linked glycosylation protein 9 homolog; dol-P-Man dependent alpha-1,2-mannosyltransferase; dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; loss of heterozygosity, 11, chromosomal region 1 gene J product; asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog; dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase; dolichyl-P-Man:Man(8)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase; asparagine-linked glycosylation 9 homolog (yeast, alpha- 1,2-mannosyltransferase); asparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase)
UniProt Protein Name:Alpha-1,2-mannosyltransferase ALG9
UniProt Synonym Protein Names:Asparagine-linked glycosylation protein 9 homolog; Disrupted in bipolar disorder protein 1; Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Protein Family:Alpha-1,2-mannosyltransferase
UniProt Gene Name:ALG9  
UniProt Entry Name:ALG9_HUMAN
Anti-ALG9 Antibody (CAB17213)Western blot analysis of extracts of various cell lines, using ALG9 antibody (CAB17213) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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