Name: Anti-ALDH3B1 Antibody (CAB10415)
Brand: Cell Biology Antibodies 1
SKU: CAB10415
Availability: OutOfStock

Antibody Name:	Anti-ALDH3B1 Antibody
Antibody SKU:	CAB10415
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ALDH3B1 (NP_001025181.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, Mouse kidney, Mouse liver, Rat lung

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ALDH3B1 (NP_001025181.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MDPL GDTL RRLR EAFH AGRT RPAE FRAA QLQG LGRF LQEN KQLL HDAL AQDL HKAT QLDS AFIR KEPF GLVL IIAP WNYP
Gene ID:	221
Uniprot:	P43353
Cellular Location:	Cell membrane, Lipid-anchor
Calculated MW:	47kDa/51kDa
Observed MW:	52kDa

Synonyms:

ALDH3B1, ALDH4, ALDH7

Background:

This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	ALDH3B1: Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Oxidoreductase; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - phenylalanine; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.2.1.5; Carbohydrate Metabolism - glycolysis and gluconeogenesis Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cytoplasm; plasma membrane; vesicle Molecular Function:3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; protein binding Biological Process: alcohol metabolic process; aldehyde catabolic process; lipid metabolic process; sphingolipid biosynthetic process
NCBI Summary:	This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Code:	P43353
NCBI GenInfo Identifier:	1169285
NCBI Gene ID:	221
NCBI Accession:	P43353.1
UniProt Secondary Accession:	P43353,Q53XL5, Q8N515, Q96CK8, A3FMP9,
UniProt Related Accession:	P43353
Molecular Weight:	47,683 Da
NCBI Full Name:	Aldehyde dehydrogenase family 3 member B1
NCBI Synonym Full Names:	aldehyde dehydrogenase 3 family member B1
NCBI Official Symbol:	ALDH3B1
NCBI Official Synonym Symbols:	ALDH4; ALDH7
NCBI Protein Information:	aldehyde dehydrogenase family 3 member B1
UniProt Protein Name:	Aldehyde dehydrogenase family 3 member B1
UniProt Synonym Protein Names:	Aldehyde dehydrogenase 7
Protein Family:	Aldehyde dehydrogenase family
UniProt Gene Name:	ALDH3B1
UniProt Entry Name:	AL3B1_HUMAN

Western blot analysis of extracts of various cell lines, using ALDH3B1 antibody (CAB10415) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

Antibodies

ALDH3B1 Antibody (PACO00387)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)