Neuroscience
Anti-ALDH1A3 Antibody (CAB15230)
- SKU:
- CAB15230
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-ALDH1A3 Antibody |
| Antibody SKU: | CAB15230 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ALDH1A3 (NP_000684.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ALDH1A3 (NP_000684.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATA NGAV ENGQ PDRK PPAL PRPI RNLE VKFT KIFI NNEW HESK SGKK FATC NPST REQI CEVE EGDK PDVD KAVE AAQV AFQR GSPW RRLD ALSR GRLL HQLA DLVE RDRA TLAA LETM DTGK PFLH AFFI DLEG CIRT |
| Gene ID: | 220 |
| Uniprot: | P47895 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 56kDa |
| Observed MW: | 50kDa |
| Synonyms: | ALDH1A3, ALDH1A6, ALDH6, MCOP8, RALDH3 |
| Background: | This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ALDH1A3: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system. Belongs to the aldehyde dehydrogenase family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Amino Acid Metabolism - histidine; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.2.1.5; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine Chromosomal Location of Human Ortholog: 15q26.3 Cellular Component: cytoplasm; cytosol Molecular Function:aldehyde dehydrogenase (NAD) activity; protein homodimerization activity; aldehyde dehydrogenase [NAD(P)+] activity; retinal dehydrogenase activity Biological Process: inner ear morphogenesis; retinal metabolic process; righting reflex; embryonic eye morphogenesis; retinol metabolic process; positive regulation of apoptosis; olfactory pit development; retinoic acid metabolic process; optic cup morphogenesis involved in camera-type eye development; locomotory behavior; neuromuscular process controlling balance; nucleus accumbens development Disease: Microphthalmia, Isolated 8 |
| NCBI Summary: | This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
| UniProt Code: | P47895 |
| NCBI GenInfo Identifier: | 52788258 |
| NCBI Gene ID: | 220 |
| NCBI Accession: | P47895.2 |
| UniProt Related Accession: | P47895 |
| Molecular Weight: | |
| NCBI Full Name: | Aldehyde dehydrogenase family 1 member A3 |
| NCBI Synonym Full Names: | aldehyde dehydrogenase 1 family member A3 |
| NCBI Official Symbol: | ALDH1A3 |
| NCBI Official Synonym Symbols: | ALDH6; MCOP8; RALDH3; ALDH1A6 |
| NCBI Protein Information: | aldehyde dehydrogenase family 1 member A3 |
| UniProt Protein Name: | Aldehyde dehydrogenase family 1 member A3 |
| UniProt Synonym Protein Names: | Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3 |
| UniProt Gene Name: | ALDH1A3 |
| UniProt Entry Name: | AL1A3_HUMAN |
 | Western blot analysis of extracts of mouse pancreas, using ALDH1A3 antibody (CAB15230) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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