Cell Biology Antibodies 16
Anti-ALDH1A1 Antibody (CAB0157)
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- SKU:
- CAB0157
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ALDH1A1 Antibody |
| Antibody SKU: | CAB0157 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ALDH1A1 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, A-549, K-562, Mouse lung, Mouse testis, Rat lung, Rat liver, Rat kidney |
| Immunogen: | A synthesized peptide derived from human ALDH1A1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 216 |
| Uniprot: | P00352 |
| Cellular Location: | |
| Calculated MW: | 55kDa |
| Observed MW: | 55KDa |
 | Western blot - ALDH1A1 Rabbit mAb (CAB0157) |
| Synonyms: | ALDC, ALDH-E1, ALDH1, ALDH11, HEL-9, HEL-S-53e, HEL12, PUMB1, RALDH1 |
| Background: | The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011] |
| UniProt Protein Function: | ALDH1A1: Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family. |
| UniProt Protein Details: | Protein type:GAPs, Ras; EC 1.2.1.36; GAPs; Cofactor and Vitamin Metabolism - retinol; Apoptosis; Oxidoreductase Chromosomal Location of Human Ortholog: 9q21.13 Cellular Component: cytoplasm; cytosol Molecular Function:aldehyde dehydrogenase (NAD) activity; androgen binding; 3-chloroallyl aldehyde dehydrogenase activity; benzaldehyde dehydrogenase (NAD+) activity; retinal dehydrogenase activity Biological Process: retinol metabolic process; xenobiotic metabolic process; aldehyde metabolic process; ethanol oxidation |
| NCBI Summary: | The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011] |
| UniProt Code: | P00352 |
| NCBI GenInfo Identifier: | 118495 |
| NCBI Gene ID: | 216 |
| NCBI Accession: | P00352.2 |
| UniProt Related Accession: | P00352 |
| Molecular Weight: | ~ 50-55kDa |
| NCBI Full Name: | Retinal dehydrogenase 1 |
| NCBI Synonym Full Names: | aldehyde dehydrogenase 1 family member A1 |
| NCBI Official Symbol: | ALDH1A1 |
| NCBI Official Synonym Symbols: | ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e |
| NCBI Protein Information: | retinal dehydrogenase 1 |
| UniProt Protein Name: | Retinal dehydrogenase 1 |
| UniProt Synonym Protein Names: | ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic |
| Protein Family: | Retinal dehydrogenase |
| UniProt Gene Name: | ALDH1A1 |
| UniProt Entry Name: | AL1A1_HUMAN |
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