Cell Biology Antibodies 3

Anti-AKR1C1 Antibody (CAB13004)

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SKU:
CAB13004
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-AKR1C1 Antibody
Antibody SKU:CAB13004
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C1 (NP_001344.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:3000
Reactivity:Human, Mouse
Positive Samples:HeLa, 22Rv1, U-87MG, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C1 (NP_001344.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDSK YQCV KLND GHFM PVLG FGTY APAE VPKS KALE ATKL AIEA GFRH IDSA HLYN NEEQ VGLA IRSK IADG SVKR EDIF YTSK LWCN SHRP ELVR PALE RSLK NLQL DYVD LYLI HFPV SVKP GEEV IPKD ENGK ILFD TVDL CATW EAVE KCKD AGLA KSIG VSNF NRRQ LEMI LNKP GLKY KPVC NQVE CHPY FNQR KLLD FCKS KDIV LVAY SALG SHRE EPWV DPNS PVLL EDPV LCAL AKKH KRTP ALIA LRYQ LQRG VVVL AKSY NEQR IRQN VQVF EFQL TSEE MKAI DGLN RNVR YLTL DIFA GPPN YPFS DEY
Gene ID:1645
Uniprot:Q04828
Cellular Location:Cytoplasm
Calculated MW:36kDa
Observed MW:38kDa
Synonyms:AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
Background:This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
UniProt Protein Function:Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
NCBI Summary:This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
UniProt Code:Q04828
NCBI GenInfo Identifier:416877
NCBI Gene ID:1645
NCBI Accession:Q04828.1
UniProt Secondary Accession:Q04828,P52896, Q5SR15, Q7M4N2, Q9UCX2,
UniProt Related Accession:Q04828
Molecular Weight:36 kDa
NCBI Full Name:Aldo-keto reductase family 1 member C1
NCBI Synonym Full Names:aldo-keto reductase family 1 member C1
NCBI Official Symbol:AKR1C1  
NCBI Official Synonym Symbols:C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD  
NCBI Protein Information:aldo-keto reductase family 1 member C1
UniProt Protein Name:Aldo-keto reductase family 1 member C1
UniProt Synonym Protein Names:20-alpha-hydroxysteroid dehydrogenase (EC:1.1.1.149
Protein Family:Aldo-keto reductase family
UniProt Gene Name:AKR1C1  
Anti-AKR1C1 Antibody (CAB13004)Western blot analysis of extracts of various cell lines, using AKR1C1 antibody (CAB13004) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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