Name: Anti-AKR1B10 Antibody (CAB7823)
Brand: Cell Biology Antibodies 11
SKU: CAB7823
Availability: OutOfStock

Antibody Name:	Anti-AKR1B10 Antibody
Antibody SKU:	CAB7823
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B10 (NP_064695.3).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, Mouse small intestine, Mouse stomach, Mouse liver, Mouse kidney, Rat small intestine

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B10 (NP_064695.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MATF VELS TKAK MPIV GLGT WKSP LGKV KEAV KVAI DAGY RHID CAYV YQNE HEVG EAIQ EKIQ EKAV KRED LFIV SKLW PTFF ERPL VRKA FEKT LKDL KLSY LDVY LIHW PQGF KSGD DLFP KDDK GNAI GGKA TFLD AWEA MEEL VDEG LVKA LGVS NFSH FQIE KLLN KPGL KYKP VTNQ VECH PYLT QEKL IQYC HSKG ITVT AYSP LGSP DRPW AKPE DPSL LEDP KIKE IAAK HKKT AAQV LIRF HIQR NVIV IPKS VTPA RIVE NIQV FDFK LSDE EMAT ILSF NRNW RACN VLQS SHLE DYPF NAEY
Gene ID:	57016
Uniprot:	O60218
Cellular Location:	Lysosome, Secreted
Calculated MW:	36kDa
Observed MW:	36kDa

Synonyms:	AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
Background:	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.

UniProt Protein Function:	AKR1B10: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. Belongs to the aldo/keto reductase family.
UniProt Protein Details:	Protein type:Lipid Metabolism - linoleic acid; Oxidoreductase; EC 1.1.1.21; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.- Chromosomal Location of Human Ortholog: 7q33 Cellular Component: cytosol Molecular Function:aldo-keto reductase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; protein binding; retinal dehydrogenase activity Biological Process: aldehyde metabolic process; digestion; farnesol catabolic process; retinoid metabolic process; steroid metabolic process
NCBI Summary:	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
UniProt Code:	O60218
NCBI GenInfo Identifier:	322510010
NCBI Gene ID:	57016
NCBI Accession:	O60218.2
UniProt Secondary Accession:	O60218,O75890, Q6FHF3, Q8IWZ1, A4D1P1,
UniProt Related Accession:	O60218
Molecular Weight:	36,020 Da
NCBI Full Name:	Aldo-keto reductase family 1 member B10
NCBI Synonym Full Names:	aldo-keto reductase family 1 member B10
NCBI Official Symbol:	AKR1B10
NCBI Official Synonym Symbols:	HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12
NCBI Protein Information:	aldo-keto reductase family 1 member B10
UniProt Protein Name:	Aldo-keto reductase family 1 member B10
UniProt Synonym Protein Names:	ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase
Protein Family:	Aldo-keto reductase family
UniProt Gene Name:	AKR1B10
UniProt Entry Name:	AK1BA_HUMAN

Western blot analysis of extracts of various cell lines, using AKR1B10 antibody (CAB7823) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

ELISA Kits

Human Aldo-keto reductase family 1 member B10 / AKR1B10 ELISA Kit

Human Aldo-keto reductase family 1 member B10 (AKR1B10) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)