Antibody Name:	Anti-AIP Antibody
Antibody SKU:	CAB9852
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human AIP (NP_003968.3).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:	Human, Mouse
Positive Samples:	B cells, SH-SY5Y, Raji, MCF7, SW620

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human AIP (NP_003968.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MADI IARL REDG IQKR VIQE GRGE LPDF QDGT KATF HYRT LHSD DEGT VLDD SRAR GKPM ELII GKKF KLPV WETI VCTM REGE IAQF LCDI KHVV LYPL VAKS LRNI AVGK DPLE GQRH CCGV AQMR EHSS LGHA DLDA LQQN PQPL IFHM EMLK VESP GTYQ QDPW AMTD EEKA KAVP LIHQ EGNR LYRE GHVK EAAA KYYD AIAC LKNL QMKE QPGS PEWI QLDQ QITP LLLN YCQC KLVV EEYY EVLD HCSS ILNK YDDN VKAY FKRG KAHA AVWN AQEA QADF AKVL ELDP ALAP VVSR ELRA LEAR IRQK DEED KARF RGIF SH
Gene ID:	9049
Uniprot:	O00170
Cellular Location:	Cytoplasm
Calculated MW:	37kDa
Observed MW:	37kDa

Synonyms:

AIP, ARA9, FKBP16, FKBP37, SMTPHN, XAP-2, XAP2

Background:

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	Function: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.Cellular negative regulator of the hepatitis B virus (HBV) X protein.
UniProt Protein Details:	Subunit structure: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex. Ref.9 Subcellular location: Cytoplasm. Tissue specificity: Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver. Involvement in Disease: Growth hormone-secreting pituitary adenoma (GHSPA) [MIM:102200]: Pituitary adenomas include somatotropinoma and prolactinoma.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4 Ref.8 Ref.10 Ref.11ACTH-secreting pituitary adenoma (ASPA) [MIM:219090]: A pituitary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.Note: The disease is caused by mutations affecting the gene represented in this entry.Prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]: Most common type of hormonally active pituitary adenoma.Note: The disease is caused by mutations affecting the gene represented in this entry. Sequence similarities: Contains 1 PPIase FKBP-type domain.Contains 2 TPR repeats.
NCBI Summary:	The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. [provided by RefSeq, Sep 2008]
UniProt Code:	O00170
NCBI GenInfo Identifier:	254763247
NCBI Gene ID:	9049
NCBI Accession:	O00170.2
UniProt Secondary Accession:	O00170,Q2M3Q2, Q99606, A0SZW3, A0SZW4, A0SZW5, A0SZW6
UniProt Related Accession:	O00170
Molecular Weight:	37,636 Da
NCBI Full Name:	AH receptor-interacting protein
NCBI Synonym Full Names:	aryl hydrocarbon receptor interacting protein
NCBI Official Symbol:	AIP
NCBI Official Synonym Symbols:	ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
NCBI Protein Information:	AH receptor-interacting protein; immunophilin homolog ARA9; HBV X-associated protein 2
UniProt Protein Name:	AH receptor-interacting protein
UniProt Synonym Protein Names:	Aryl-hydrocarbon receptor-interacting protein; HBV X-associated protein 2; XAP-2; Immunophilin homolog ARA9
Protein Family:	AH receptor-interacting protein
UniProt Gene Name:	AIP
UniProt Entry Name:	AIP_HUMAN

	Western blot analysis of extracts of various cell lines, using AIP antibody (CAB9852) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded mouse kidney using AIP antibody (CAB9852) at dilution of 1:100 (40x lens).