Cell Death Antibodies 2

Anti-AIFM3 Antibody (CAB8597)

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SKU:
CAB8597
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death

Description

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Antibody Name:Anti-AIFM3 Antibody
Antibody SKU:CAB8597
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human AIFM3 (NP_001018070.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:THP-1, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human AIFM3 (NP_001018070.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGGC FSKP KPVE LKIE VVLP EKER GKEE LSAS GKGS PRAY QGNG TARH FHTE ERLS TPHP YPSP QDCV EAAV CHVK DLEN GQMR EVEL GWGK VLLV KDNG EFHA LGHK CPHY GAPL VKGV LSRG RVRC PWHG ACFN ISTG DLED FPGL DSLH KFQV KIEK EKVY VRAS KQAL QLQR RTKV MAKC ISPS AGYS SSTN VLIV
Gene ID:150209
Uniprot:Q96NN9
Cellular Location:Mitochondrion
Calculated MW:65kDa/66kDa
Observed MW:72kDa
Synonyms:AIFM3, AIFL
Background:
UniProt Protein Function:AIFM3: Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. Belongs to the FAD-dependent oxidoreductase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Endoplasmic reticulum; Mitochondrial; Apoptosis; EC 1.-.-.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: mitochondrion; endoplasmic reticulum; mitochondrial inner membrane; nucleus

Molecular Function:2 iron, 2 sulfur cluster binding; FAD binding; metal ion binding; oxidoreductase activity

Biological Process: cell redox homeostasis

UniProt Code:Q96NN9
NCBI GenInfo Identifier:74732608
NCBI Gene ID:150209
NCBI Accession:Q96NN9.1
UniProt Secondary Accession:Q96NN9,Q6ZT44, Q8N1V3, Q8N5E0, B7WP37, D3DX37, D3DX38
UniProt Related Accession:Q96NN9
Molecular Weight:65,966 Da
NCBI Full Name:Apoptosis-inducing factor 3
NCBI Synonym Full Names:apoptosis-inducing factor, mitochondrion-associated, 3
NCBI Official Symbol:AIFM3  
NCBI Official Synonym Symbols:AIFL  
NCBI Protein Information:apoptosis-inducing factor 3; apoptosis-inducing factor like
UniProt Protein Name:Apoptosis-inducing factor 3
UniProt Synonym Protein Names:Apoptosis-inducing factor-like protein
Protein Family:Apoptosis-inducing factor
UniProt Gene Name:AIFM3  
UniProt Entry Name:AIFM3_HUMAN
Anti-AIFM3 Polyclonal Antibody (CAB8597)Western blot analysis of extracts of various cell lines, using AIFM3 antibody (CAB8597) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-AIFM3 Polyclonal Antibody (CAB8597)Immunohistochemistry of paraffin-embedded rat kidney using AIFM3 antibody (CAB8597) at dilution of 1:100 (40x lens).
Anti-AIFM3 Polyclonal Antibody (CAB8597)Immunohistochemistry of paraffin-embedded human liver cancer using AIFM3 antibody (CAB8597) at dilution of 1:100 (40x lens).
Anti-AIFM3 Polyclonal Antibody (CAB8597)Immunohistochemistry of paraffin-embedded mouse brain using AIFM3 antibody (CAB8597) at dilution of 1:100 (40x lens).
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