Epigenetics & Nuclear Signaling Antibodies 1
Anti-AICDA Antibody (CAB12372)
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- SKU:
- CAB12372
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-AICDA Antibody |
| Antibody SKU: | CAB12372 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-130 of human AICDA (NP_065712.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-130 of human AICDA (NP_065712.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NVRW AKGR RETY LCYV VKRR DSAT SFSL DFGY LRNK NGCH VELL FLRY ISDW DLDP GRCY RVTW FTSW SPCY DCAR HVAD FLRG NPNL SLRI FTAR LYFC EDRK AEPE GLRR LH |
| Gene ID: | 57379 |
| Uniprot: | Q9GZX7 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 22kDa/23kDa |
| Observed MW: | 24kDa |
| Synonyms: | AICDA, AID, ARP2, CDA2, HEL-S-284, HIGM2 |
| Background: | This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). |
| UniProt Protein Function: | AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family. |
| UniProt Protein Details: | Protein type:EC 3.5.4.38; Hydrolase Chromosomal Location of Human Ortholog: 12p13 Cellular Component: cytoplasm; exosome (RNase complex); nucleus Molecular Function:protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing Disease: Immunodeficiency With Hyper-igm, Type 2 |
| NCBI Summary: | This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009] |
| UniProt Code: | Q9GZX7 |
| NCBI GenInfo Identifier: | 23813666 |
| NCBI Gene ID: | 57379 |
| NCBI Accession: | Q9GZX7.1 |
| UniProt Related Accession: | Q9GZX7 |
| Molecular Weight: | |
| NCBI Full Name: | Single-stranded DNA cytosine deaminase |
| NCBI Synonym Full Names: | activation induced cytidine deaminase |
| NCBI Official Symbol: | AICDA |
| NCBI Official Synonym Symbols: | AID; ARP2; CDA2; HIGM2; HEL-S-284 |
| NCBI Protein Information: | single-stranded DNA cytosine deaminase |
| UniProt Protein Name: | Single-stranded DNA cytosine deaminase |
| UniProt Synonym Protein Names: | Activation-induced cytidine deaminase; Cytidine aminohydrolase |
| Protein Family: | AIDA-I autotransporter |
| UniProt Gene Name: | AICDA |
| UniProt Entry Name: | AICDA_HUMAN |
 | Western blot analysis of extracts of mouse brain, using AICDA antibody (CAB12372) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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