Signal Transduction Antibodies 2
Anti-AHSG Antibody (CAB1647)
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- SKU:
- CAB1647
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-AHSG Antibody |
| Antibody SKU: | CAB1647 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human AHSG (NP_001613.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | 293T, HepG2, DU145, A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human AHSG (NP_001613.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APHG PGLI YRQP NCDD PETE EAAL VAID YINQ NLPW GYKH TLNQ IDEV KVWP QQPS GELF EIEI DTLE TTCH VLDP TPVA RCSV RQLK EHAV EGDC DFQL LKLD GKFS VVYA KCDS SPDS AEDV RKVC QDCP LLAP LNDT RVVH AAKA ALAA FNAQ NNGS NFQL EEIS RAQL VPLP PSTY VEFT VSGT DCVA KEAT EAAK CNLL AEKQ YGFC KATL SEKL GGAE VAVT CMVF QTQP VSSQ PQPE GANE AVPT PVVD PDAP PSPP LGAP GLPP AGSP PDSH VL |
| Gene ID: | 197 |
| Uniprot: | P02765 |
| Cellular Location: | Secreted |
| Calculated MW: | 39kDa |
| Observed MW: | 68kDa |
| Synonyms: | AHSG, A2HS, AHS, FETUA, HSGA |
| Background: | Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. |
| UniProt Protein Function: | FETUA: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Belongs to the fetuin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3q27 Cellular Component: extracellular space; extracellular region Molecular Function:kinase inhibitor activity; cysteine protease inhibitor activity Biological Process: negative regulation of bone mineralization; pinocytosis; ossification; positive regulation of phagocytosis; regulation of inflammatory response; acute-phase response; negative regulation of phosphorylation; negative regulation of insulin receptor signaling pathway; skeletal development; regulation of bone mineralization |
| NCBI Summary: | Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02765 |
| NCBI GenInfo Identifier: | 112910 |
| NCBI Gene ID: | 197 |
| NCBI Accession: | P02765.1 |
| UniProt Secondary Accession: | P02765,O14961, O14962, Q9P152, A8K9N6, B2R7G1, |
| UniProt Related Accession: | P02765,AAB29984 |
| Molecular Weight: | 39,325 Da |
| NCBI Full Name: | Alpha-2-HS-glycoprotein |
| NCBI Synonym Full Names: | alpha-2-HS-glycoprotein |
| NCBI Official Symbol: | AHSG |
| NCBI Official Synonym Symbols: | AHS; A2HS; HSGA; FETUA |
| NCBI Protein Information: | alpha-2-HS-glycoprotein; fetuin-A; alpha-2-Z-globulin; ba-alpha-2-glycoprotein |
| UniProt Protein Name: | Alpha-2-HS-glycoprotein |
| UniProt Synonym Protein Names: | Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-ACleaved into the following 2 chains:Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B |
| Protein Family: | Alpha-2-HS-glycoprotein |
| UniProt Gene Name: | AHSG |
| UniProt Entry Name: | FETUA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AHSG antibody (CAB1647) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of MCF-7 cells using AHSG antibody (CAB1647). Blue: DAPI for nuclear staining. |
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