Metabolism Antibodies 2
Anti-AHCYL1 Antibody (CAB7773)
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- SKU:
- CAB7773
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-AHCYL1 Antibody |
| Antibody SKU: | CAB7773 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-260 of human AHCYL1 (NP_006612.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, U-251MG, SKOV3, Mouse brain, Rat spinal cord |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-260 of human AHCYL1 (NP_006612.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATV TKAP KKQI QFAD DMQE FTKF PTKT GRRS LSRS ISQS STDS YSSA ASYT DSSD DEVS PREK QQTN SKGS SNFC VKNI KQAE FGRR EIEI AEQD MSAL ISLR KRAQ GEKP LAGA KIVG CTHI TAQT AVLI ETLC ALGA QCRW SACN IYST QNEV AAAL AEAG VAVF AWKG ESED DFWW CIDR CVNM DGWQ ANMI LDDG GDLT HWVY KKYP NVFK KIRG IVEE SVTG VH |
| Gene ID: | 10768 |
| Uniprot: | O43865 |
| Cellular Location: | Apical cell membrane, Cytoplasm, Endoplasmic reticulum, Microsome, cytosol |
| Calculated MW: | 53kDa/58kDa |
| Observed MW: | 59kDa |
| Synonyms: | AHCYL1, DCAL, IRBIT, PPP1R78, PRO0233, XPVKONA |
| Background: | The protein encoded by this gene interacts with inositol 1, 4, 5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. |
| NCBI Summary: | This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011] |
| UniProt Code: | O43865 |
| NCBI GenInfo Identifier: | 109731743 |
| NCBI Gene ID: | 9628 |
| NCBI Accession: | BC113572 |
| UniProt Secondary Accession: | O43865,O75576, O75577, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6 Q8TE13, Q8TE14, Q8TE15, C9JE95, F8W7W5, |
| UniProt Related Accession: | P49758 |
| Molecular Weight: | 53,319 Da |
| NCBI Full Name: | Homo sapiens regulator of G-protein signaling 6, mRNA |
| NCBI Synonym Full Names: | regulator of G-protein signaling 6 |
| NCBI Official Symbol: | RGS6 |
| NCBI Official Synonym Symbols: | GAP; S914; HA117 |
| NCBI Protein Information: | regulator of G-protein signaling 6 |
| UniProt Protein Name: | Putative adenosylhomocysteinase 2 |
| UniProt Synonym Protein Names: | DC-expressed AHCY-like molecule; IP(3)Rs binding protein released with IP(3); IRBIT; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like protein 1 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | AHCYL1 |
| UniProt Entry Name: | SAHH2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AHCYL1 antibody (CAB7773) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human stomach using AHCYL1 antibody (CAB7773) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat kidney using AHCYL1 antibody (CAB7773) at dilution of 1:100 (40x lens). |
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