Cell Biology Antibodies 3

Anti-AGTPBP1 Antibody (CAB13081)

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SKU:
CAB13081
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-AGTPBP1 Antibody
Antibody SKU:CAB13081
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 320-520 of human AGTPBP1 (NP_056054.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Jurkat, 293T, A-549, Mouse pancreas, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 320-520 of human AGTPBP1 (NP_056054.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PPEV DDVV DESD DNDD IDVE AENE TENE DDLD QNFK NDDI ETDI NKLK PQQE PGRT IEDL KMYE HLFP ELVD DFQD YDLI SKEP KPFV FEGK VRGP IVVP TAGE ETSG NSGN LRKV VMKE NISS KGDE GEKK STFM DLAK EDIK DNDR TLQQ QPGD QNRT ISSV HGLN NDIV KALD RITL QNIP SQTA PGFT AEMK KDCS L
Gene ID:23287
Uniprot:Q9UPW5
Cellular Location:Cytoplasm, Mitochondrion, Nucleus, cytosol
Calculated MW:133kDa/138kDa
Observed MW:138kDa
Synonyms:AGTPBP1, CCP1, NNA1
Background:
UniProt Protein Function:Nna1: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Interacts with MYLK. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.17.-; Protease

Chromosomal Location of Human Ortholog: 9q21.33

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleus

Molecular Function:metallocarboxypeptidase activity; tubulin binding

Biological Process: cerebellar Purkinje cell differentiation; eye photoreceptor cell differentiation; mitochondrion organization and biogenesis; neuromuscular process; olfactory bulb development

NCBI Summary:NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]
UniProt Code:Q9UPW5
NCBI GenInfo Identifier:160019039
NCBI Gene ID:23287
NCBI Accession:Q9UPW5.3
UniProt Secondary Accession:Q9UPW5,Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8 Q9NVK1, B4DIT6, B4DRZ8,
UniProt Related Accession:Q9UPW5
Molecular Weight:138,647 Da
NCBI Full Name:Cytosolic carboxypeptidase 1
NCBI Synonym Full Names:ATP/GTP binding protein 1
NCBI Official Symbol:AGTPBP1  
NCBI Official Synonym Symbols:CCP1; NNA1  
NCBI Protein Information:cytosolic carboxypeptidase 1
UniProt Protein Name:Cytosolic carboxypeptidase 1
UniProt Synonym Protein Names:ATP/GTP-binding protein 1; Nervous system nuclear protein induced by axotomy protein 1 homolog
UniProt Gene Name:AGTPBP1  
UniProt Entry Name:CBPC1_HUMAN
Anti-AGTPBP1 Antibody (CAB13081)Western blot analysis of extracts of various cell lines, using AGTPBP1 antibody (CAB13081) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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