Signal Transduction Antibodies 3
Anti-AGRP Antibody (CAB8044)
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- SKU:
- CAB8044
- Product Type:
- Antibody
- Applications:
- IHC
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | AGRP Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8044 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-132 of human AGRP (NP_001129.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:200 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-132 of human AGRP (NP_001129.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AQMG LAPM EGIR RPDQ ALLP ELPG LGLR APLK KTTA EQAE EDLL QEAQ ALAE VLDL QDRE PRSS RRCV RLHE SCLG QQVP CCDP CATC YCRF FNAF CYCR KLGT AMNP CSRT |
| Gene ID: | 181 |
| Uniprot: | O00253 |
| Cellular Location: | Golgi apparatus lumen, Secreted |
| Calculated MW: | 14kDa |
| Observed MW: | Refer to figures |
| Synonyms: | AGRP, AGRT, ART, ASIP2 |
| Background: | This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. |
| UniProt Protein Function: | AGRP: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. Genetic variations in AGRP may be a cause of obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. |
| UniProt Protein Details: | Protein type:Secreted; Hormone; Secreted, signal peptide Chromosomal Location of Human Ortholog: 16q22 Cellular Component: extracellular space; cell soma; Golgi lumen Molecular Function:neuropeptide hormone activity; receptor binding Biological Process: maternal process involved in pregnancy; hormone-mediated signaling; eating behavior; neuropeptide signaling pathway; photoperiodism; feeding behavior; adult feeding behavior; response to insulin stimulus Disease: Obesity |
| NCBI Summary: | This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009] |
| UniProt Code: | O00253 |
| NCBI GenInfo Identifier: | 4501995 |
| NCBI Gene ID: | 181 |
| NCBI Accession: | NP_001129.1 |
| UniProt Secondary Accession: | O00253,O15459, Q2TBD9, |
| UniProt Related Accession: | O00253 |
| Molecular Weight: | |
| NCBI Full Name: | agouti-related protein |
| NCBI Synonym Full Names: | agouti related neuropeptide |
| NCBI Official Symbol: | AGRP |
| NCBI Official Synonym Symbols: | ART; AGRT; ASIP2 |
| NCBI Protein Information: | agouti-related protein; agouti related protein homolog |
| UniProt Protein Name: | Agouti-related protein |
| Protein Family: | Agouti-related protein |
| UniProt Gene Name: | AGRP |
| UniProt Entry Name: | AGRP_HUMAN |
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