Cardiovascular Antibodies

Anti-AGGF1 Antibody (CAB8228)

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SKU:
CAB8228
Product Type:
Antibody
Applications:
WB
Applications:
IF
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular

Description

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Antibody Name:AGGF1 Rabbit Polyclonal Antibody
Antibody SKU:CAB8228
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human AGGF1 (NP_060516.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:HeLa, U-251MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human AGGF1 (NP_060516.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASE APSP PRSP PPPT SPEP ELAQ LRRK VEKL EREL RSCK RQVR EIEK LLHH TERL YQNA ESNN QELR TQ
Gene ID:55109
Uniprot:Q8N302
Cellular Location:Cytoplasm, Secreted
Calculated MW:12kDa/20kDa/80kDa
Observed MW:81kDa
Synonyms:AGGF1, GPATC7, GPATCH7, HSU84971, HUS84971, VG5Q
Background:This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.
UniProt Protein Function:AGGF1: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Defects in AGGF1 are a cause of Klippel-Trenaunay syndrome (KTS). KTS is a congenital disease characterized by malformations of capillary (98% of KTS patients), venous (72%) and lymphatic (11%) vessels, and bony and soft tissue hypertrophy that leads to large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA processing; Cell adhesion

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: cytoplasm; extracellular region; perinuclear region of cytoplasm

Molecular Function:protein binding

Biological Process: cell adhesion; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; RNA processing; vasculogenesis

Disease: Klippel-trenaunay-weber Syndrome

NCBI Summary:This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]
UniProt Code:Q8N302
NCBI GenInfo Identifier:45477317
NCBI Gene ID:55109
NCBI Accession:Q8N302.2
UniProt Secondary Accession:Q8N302,O00581, Q53YS3, Q9BU84, Q9NW66,
UniProt Related Accession:Q8N302
Molecular Weight:20,506 Da
NCBI Full Name:Angiogenic factor with G patch and FHA domains 1
NCBI Synonym Full Names:angiogenic factor with G-patch and FHA domains 1
NCBI Official Symbol:AGGF1  
NCBI Official Synonym Symbols:VG5Q; GPATC7; GPATCH7; HSU84971; HUS84971  
NCBI Protein Information:angiogenic factor with G patch and FHA domains 1
UniProt Protein Name:Angiogenic factor with G patch and FHA domains 1
UniProt Synonym Protein Names:Angiogenic factor VG5Q; hVG5Q; G patch domain-containing protein 7; Vasculogenesis gene on 5q protein
Protein Family:Angiogenic factor with G patch and FHA domains
UniProt Gene Name:AGGF1  
UniProt Entry Name:AGGF1_HUMAN
Anti-AGGF1 Polyclonal Antibody (CAB8228)Western blot analysis of extracts of various cell lines, using AGGF1 antibody (CAB8228) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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