Metabolism Antibodies 2
Anti-ADSS Antibody (CAB6516)
- SKU:
- CAB6516
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-ADSS Antibody |
| Antibody SKU: | CAB6516 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ADSS (NP_001117.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, Mouse lung, Mouse kidney, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ADSS (NP_001117.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAFA ETYP AASS LPNG DCGR PRAR PGGN RVTV VLGA QWGD EGKG KVVD LLAQ DADI VCRC QGGN NAGH TVVV DSVE YDFH LLPS GIIN PNVT AFIG NGVV IHLP GLFE EAEK NVQK GKGL EGWE KRLI ISDR AHIV FDFH QAAD GIQE QQRQ EQAG KNLG TTKK GIGP VYSS KAAR SGLR MCDL VSDF DGFS ERFK VLAN QYKS IYPT LEID IEGE LQKL KGYM EKIK PMVR DGVY FLYE ALHG PPKK ILVE GANA ALLD IDFG TYPF VTSS NCTV GGVC |
| Gene ID: | 159 |
| Uniprot: | P30520 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 50kDa |
| Observed MW: | 50kDa |
| Synonyms: | ADSS, ADEH, ADSS 2, ADSS2 |
| Background: | This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17. |
| UniProt Protein Function: | ADSS: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family. |
| UniProt Protein Details: | Protein type:EC 6.3.4.4; Nucleotide Metabolism - purine; Ligase; Amino Acid Metabolism - alanine, aspartate and glutamate Chromosomal Location of Human Ortholog: 1q44 Cellular Component: cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; GTP binding; magnesium ion binding; phosphate binding; adenylosuccinate synthase activity Biological Process: AMP biosynthetic process; response to purine; purine ribonucleoside monophosphate biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; immune system process; IMP metabolic process; aspartate metabolic process; purine base metabolic process |
| NCBI Summary: | This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010] |
| UniProt Code: | P30520 |
| NCBI GenInfo Identifier: | 21264498 |
| NCBI Gene ID: | 159 |
| NCBI Accession: | P30520.3 |
| UniProt Secondary Accession: | P30520,Q96EG7, B1AQM5, |
| UniProt Related Accession: | P30520 |
| Molecular Weight: | 456 |
| NCBI Full Name: | Adenylosuccinate synthetase isozyme 2 |
| NCBI Synonym Full Names: | adenylosuccinate synthase |
| NCBI Official Symbol: | ADSS |
| NCBI Official Synonym Symbols: | ADEH; ADSS 2 |
| NCBI Protein Information: | adenylosuccinate synthetase isozyme 2; adSS 2; AMPSase 2; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase; adenylosuccinate synthetase, liver isozyme; adenylosuccinate synthetase, acidic isozyme; adenylosuccinate synthetase (Ade(-)H-complementing) |
| UniProt Protein Name: | Adenylosuccinate synthetase isozyme 2 |
| UniProt Synonym Protein Names: | Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme; IMP--aspartate ligase 2 |
| Protein Family: | Adenylosuccinate synthetase |
| UniProt Gene Name: | ADSS |
| UniProt Entry Name: | PURA2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADSS antibody (CAB6516) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of MCF7 cells using ADSS antibody (CAB6516). Blue: DAPI for nuclear staining. |
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