Cell Biology Antibodies 9

Anti-ADRM1 Antibody (CAB4481)

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SKU:
CAB4481
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ADRM1
Synonyms:
ARM-1
Synonyms:
ARM1
Synonyms:
GP110
Research Area:
Cell Biology

Description

Product Name:ADRM1 Rabbit pAb
Product Code:CAB4481
Size:20uL, 50uL, 100uL
Synonyms:ADRM1, ARM-1, ARM1, GP110
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 108-407 of human ADRM1 (NP_008933.2).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:1000 - 1:4000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, LO2, 293T, MCF7, SW480
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 108-407 of human ADRM1 (NP_008933.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WMQE PKTD QDEE HCRK VNEY LNNP PMPG ALGA SGSS GHEL SALG GEGG LQSL LGNM SHSQ LMQL IGPA GLGG LGGL GALT GPGL ASLL GSSG PPGS SSSS SSRS QSAA VTPS STTS STRA TPAP SAPA AASA TSPS PAPS SGNG ASTA ASPT QPIQ LSDL QSIL ATMN VPAG PAGG QQVD LASV LTPE IMAP ILAN ADVQ ERLL PYLP SGES LPQT ADEI QNTL TSPQ FQQA LGMF SAAL ASGQ LGPL MCQF GLPA EAVE AANK GDVE AFAK AMQN NAKP EQKE GDTK DKKD EEED MSLD
Gene ID:11047
Uniprot:Q16186
Cellular Location:Cytoplasm, Nucleus
Calculated MW:42kDa
Observed MW:42kDa
UniProt Protein Function:ADRM1: Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity. Interacts with PSMD1, ubiquitin and UCHL5. Belongs to the ADRM1 family.
UniProt Protein Details:

Protein type:Proteasome complex; Cell development/differentiation

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: proteasome complex; nucleoplasm; membrane; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function:protein binding; protease binding

Biological Process: RNA elongation from RNA polymerase II promoter; proteasome assembly

NCBI Summary:This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:Q16186
NCBI GenInfo Identifier:20141265
NCBI Gene ID:11047
NCBI Accession:Q16186.2
UniProt Related Accession:Q16186
Molecular Weight:
NCBI Full Name:Proteasomal ubiquitin receptor ADRM1
NCBI Synonym Full Names:adhesion regulating molecule 1
NCBI Official Symbol:ADRM1  
NCBI Official Synonym Symbols:ARM1; ARM-1; GP110  
NCBI Protein Information:proteasomal ubiquitin receptor ADRM1
UniProt Protein Name:Proteasomal ubiquitin receptor ADRM1
UniProt Synonym Protein Names:110 kDa cell membrane glycoprotein; Gp110; Adhesion-regulating molecule 1; ARM-1; Proteasome regulatory particle non-ATPase 13; hRpn13; Rpn13 homolog
UniProt Gene Name:ADRM1  
UniProt Entry Name:ADRM1_HUMAN
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