Cell Biology Antibodies 8

Anti-ADRBK2 Antibody (CAB2049)

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SKU:
CAB2049
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ADRBK2 Antibody
Antibody SKU:CAB2049
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ADRBK2 (NP_005151.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, SH-SY5Y, Mouse lung, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ADRBK2 (NP_005151.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MADL EAVL ADVS YLMA MEKS KATP AARA SKRI VLPE PSIR SVMQ KYLA ERNE ITFD KIFN QKIG FLLF KDFC LNEI NEAV PQVK FYEE IKEY EKLD NEED RLCR SRQI YDAY IMKE LLSC SHPF SKQA VEHV QSHL SKKQ VTST LFQP YIEE ICES LRGD IFQK FMES DKFT RFCQ WKNV ELNI HLTM NEFS VHRI IGRG GFGE VYGC RKAD TGKM YAMK CLDK KRIK MKQG ETLA LNER IMLS LVST GDCP FIVC MTYA FHTP DKLC FILD LMNG GDLH YHLS QHGV FSEK EMRF YATE
Gene ID:157
Uniprot:P35626
Cellular Location:
Calculated MW:79kDa
Observed MW:100kDa
Synonyms:GRK3, ADRBK2, BARK2
Background:The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
UniProt Protein Function:GRK3: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.15; Kinase, protein; AGC group; GRK family; BARK subfamily

Chromosomal Location of Human Ortholog: 22q12.1

Molecular Function:ATP binding; beta-adrenergic receptor kinase activity; G-protein coupled receptor kinase activity; protein kinase activity

Biological Process: protein amino acid phosphorylation; receptor internalization; signal transduction

NCBI Summary:The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
UniProt Code:P35626
NCBI GenInfo Identifier:116241253
NCBI Gene ID:157
NCBI Accession:P35626.2
UniProt Secondary Accession:P35626,Q9UGW9,
UniProt Related Accession:P35626
Molecular Weight:79,710 Da
NCBI Full Name:Beta-adrenergic receptor kinase 2
NCBI Synonym Full Names:adrenergic, beta, receptor kinase 2
NCBI Official Symbol:ADRBK2  
NCBI Official Synonym Symbols:GRK3; BARK2  
NCBI Protein Information:beta-adrenergic receptor kinase 2
UniProt Protein Name:Beta-adrenergic receptor kinase 2
UniProt Synonym Protein Names:G-protein-coupled receptor kinase 3
Protein Family:Beta-adrenergic receptor kinase
UniProt Gene Name:ADRBK2  
UniProt Entry Name:ARBK2_HUMAN
Anti-ADRBK2 Antibody (CAB2049)Western blot analysis of extracts of various cell lines, using ADRBK2 antibody (CAB2049) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 45s.
Anti-ADRBK2 Antibody (CAB2049)Immunohistochemistry of paraffin-embedded rat spinal cord using ADRBK2 Antibody (CAB2049) at dilution of 1:100 (40x lens).
Anti-ADRBK2 Antibody (CAB2049)Immunohistochemistry of paraffin-embedded mouse brain using ADRBK2 Antibody (CAB2049) at dilution of 1:100 (40x lens).
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