Cell Biology Antibodies 12
Anti-ADRB3 Antibody (CAB8607)
- SKU:
- CAB8607
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADRB3 Antibody |
| Antibody SKU: | CAB8607 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ADRB3 (NP_000016.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, K-562 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ADRB3 (NP_000016.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAPW PHEN SSLA PWPD LPTL APNT ANTS GLPG VPWE AALA GALL ALAV LATV GGNL LVIV AIAW TPRL QTMT NVFV TSLA AADL VMGL LVVP PAAT LALT |
| Gene ID: | 155 |
| Uniprot: | P13945 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 43kDa |
| Observed MW: | 47kDa |
| Synonyms: | ADRB3, BETA3AR |
| Background: | The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. |
| UniProt Protein Function: | ADRB3: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 8p12 Cellular Component: integral to plasma membrane; plasma membrane; receptor complex Molecular Function:beta-adrenergic receptor activity; beta3-adrenergic receptor activity; epinephrine binding; norepinephrine binding; protein binding; protein homodimerization activity Biological Process: adenylate cyclase activation; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; carbohydrate metabolic process; cell-cell signaling; energy reserve metabolic process; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; generation of precursor metabolites and energy; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of MAPKKK cascade; receptor-mediated endocytosis; thermoregulation Disease: Obesity |
| NCBI Summary: | The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009] |
| UniProt Code: | P13945 |
| NCBI GenInfo Identifier: | 461604 |
| NCBI Gene ID: | 155 |
| NCBI Accession: | P13945.3 |
| UniProt Secondary Accession: | P13945,Q4JFT4, |
| UniProt Related Accession: | P13945 |
| Molecular Weight: | 43,519 Da |
| NCBI Full Name: | Beta-3 adrenergic receptor |
| NCBI Synonym Full Names: | adrenoceptor beta 3 |
| NCBI Official Symbol: | ADRB3 |
| NCBI Official Synonym Symbols: | BETA3AR |
| NCBI Protein Information: | beta-3 adrenergic receptor |
| UniProt Protein Name: | Beta-3 adrenergic receptor |
| UniProt Synonym Protein Names: | Beta-3 adrenoreceptor; Beta-3 adrenoceptor |
| Protein Family: | Beta-3 adrenergic receptor |
| UniProt Gene Name: | ADRB3 |
| UniProt Entry Name: | ADRB3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADRB3 antibody (CAB8607) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunofluorescence analysis of NIH/3T3 cells using ADRB3 Rabbit pAb (CAB8607) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using ADRB3 Rabbit pAb (CAB8607) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of C6 cells using ADRB3 Rabbit pAb (CAB8607) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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